Property Summary

NCBI Gene PubMed Count 13
PubMed Score 8.82
PubTator Score 4.38

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
ovarian cancer 8492 2.85769616122879E-7
group 4 medulloblastoma 1875 2.58835507200871E-6
adrenocortical carcinoma 1427 2.10413602602266E-4
pilocytic astrocytoma 3086 0.00589800968120888
atypical teratoid/rhabdoid tumor 1095 0.0112807392314518
Endometriosis 535 0.0120848772050226

Expression

  Differential Expression (6)

Disease log2 FC p
group 4 medulloblastoma -3.100 0.000
adrenocortical carcinoma -2.394 0.000
atypical teratoid/rhabdoid tumor -1.900 0.011
pilocytic astrocytoma -1.100 0.006
Endometriosis -1.742 0.012
ovarian cancer -1.500 0.000

Synonym

Accession Q5DX21 C9JZN0 Q8N4F1 Q8N7T8 Q8NDD2 IgSF11
Symbols CT119
VSIG3
Igsf13
BT-IgSF
CXADRL1

Gene

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG

 IMPC Term (1)

Gene RIF (4)

PMID Text
26595655 Concerted role for IgSF11 and PSD-95 in the regulation of AMPAR-mediated synaptic transmission and plasticity.
16108831 IGSF11 is a good candidate of cancer-testis antigen. Furthermore, suppression of IGSF11 by siRNA retarded the growth of gastric cancer cells.
15795899 cell adhesion-inducing function of BT-IgSF suggests a role of the cell surface molecule in the development/function of the central nervous system and spermatogenesis
12207903 Molecular cloning of BT-IgSF which is preferentially expressed by brain and testis

AA Sequence

MTSQRSPLAPLLLLSLHGVAASLEVSESPGSIQVARGQPAVLPCTFTTSAALINLNVIWMVTPLSNANQP      1 - 70
EQVILYQGGQMFDGAPRFHGRVGFTGTMPATNVSIFINNTQLSDTGTYQCLVNNLPDIGGRNIGVTGLTV     71 - 140
LVPPSAPHCQIQGSQDIGSDVILLCSSEEGIPRPTYLWEKLDNTLKLPPTATQDQVQGTVTIRNISALSS    141 - 210
GLYQCVASNAIGTSTCLLDLQVISPQPRNIGLIAGAIGTGAVIIIFCIALILGAFFYWRSKNKEEEEEEI    211 - 280
PNEIREDDLPPKCSSAKAFHTEISSSDNNTLTSSNAYNSRYWSNNPKVHRNTESVSHFSDLGQSFSFHSG    281 - 350
NANIPSIYANGTHLVPGQHKTLVVTANRGSSPQVMSRSNGSVSRKPRPPHTHSYTISHATLERIGAVPVM    351 - 420
VPAQSRAGSLV                                                               421 - 431
//

Text Mined References (16)

PMID Year Title
26595655 2016 Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity.
25231870 2014 Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
24023788 2013 Gene network analysis in a pediatric cohort identifies novel lung function genes.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
22952603 2012 Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
16641997 2006 The DNA sequence, annotation and analysis of human chromosome 3.
16108831 2005 Identification of immunoglobulin superfamily 11 (IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas.
15795899 2005 BT-IgSF, a novel immunoglobulin superfamily protein, functions as a cell adhesion molecule.
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