Property Summary

NCBI Gene PubMed Count 17
PubMed Score 16.21
PubTator Score 16.07

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
breast carcinoma 1614 1.3748699852752E-10
osteosarcoma 7933 5.81973536654639E-7
medulloblastoma, large-cell 6234 6.23289703287831E-7
interstitial cystitis 2299 2.16100776303954E-6
atypical teratoid / rhabdoid tumor 4369 2.45320958789523E-6
psoriasis 6685 2.74267268998232E-5
group 3 medulloblastoma 2254 3.02331952282426E-5
malignant mesothelioma 3163 7.83047208451025E-5
nasopharyngeal carcinoma 1056 1.73065418334988E-4
primitive neuroectodermal tumor 3031 1.8907629194343E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 2.17560454047961E-4
glioblastoma 5572 3.18729070281982E-4
colon cancer 1475 4.7926628450209E-4
pediatric high grade glioma 2712 9.21059081049873E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00169469143038587
invasive ductal carcinoma 2950 0.00195380803422709
pituitary cancer 1972 0.00204651964874456
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00735518384405147
Multiple myeloma 1328 0.00807844625586731
primary pancreatic ductal adenocarcinoma 1271 0.00967808845192329
oligodendroglioma 2849 0.0108689878026232
lung cancer 4473 0.0118714051203358
pancreatic cancer 2300 0.0134856314177616
esophageal adenocarcinoma 737 0.0176010007179145
ductal carcinoma in situ 1745 0.0261540882718841
Breast cancer 3099 0.02775354434488
sarcoidosis 368 0.0301536050501114
Disease Target Count Z-score Confidence
Meningioma 27 4.517 2.3



Accession Q5BJF2 B4DS02 Q07823
Symbols MAC30


  Ortholog (9)

Species Source
Macaque OMA Inparanoid
Mouse OMA Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Horse OMA Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Chicken OMA Inparanoid
Xenopus OMA Inparanoid

Gene RIF (9)

26002575 High expression of TMEM97 is associated with glioma.
24853233 The down-regulation of MAC30 expression efficiently inhibited the proliferation of gastric cancer cells. Furthermore, the mobility of gastric cancer cells was also inhibited by down-regulation of MAC30.
23254963 MAC30 may serve as a new molecular marker to predict the lymph node metastasis and prognosis of patients with epithelial ovarian cancer
23229099 Overexpression of MAC30 is associated with non-small-cell lung cancer.
22024687 As the tumor penetrated the wall of the colon/rectum, MAC30 mRNA expression notably increased in colorectal tumors with T3+T4 stage compared to tumors with T1+T2 stage.
21079401 expression of MAC30 in the cytoplasm markedly increased from normal oral epithelial cells to primary oral squamous cell carcinoma; MAC30 expression in primary tumors with lymph node metastasis exceeded levels in those without metastasis
18070364 The most up-regulated gene was TMEM97 which encodes a transmembrane protein of unknown function (MAC30).
17143516 MAC30 protein may play a role in development of colorectal cancer, and can be considered as a prognostic factor.
15375745 MAC30 mRNA and protein expression in normal and cancerous tissue samples of the esophagus, stomach, colon and pancreas

AA Sequence

LTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK                                      141 - 176

Text Mined References (22)

PMID Year Title
27378690 2016 Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-pick type C1 disease cells.
26002575 2015 RNA interference against TMEM97 inhibits cell proliferation, migration, and invasion in glioma cells.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25566323 2014 TM6SF2 and MAC30, new enzyme homologs in sterol metabolism and common metabolic disease.
25080503 2014 Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels.
24853233 2014 Down-regulated MAC30 expression inhibits proliferation and mobility of human gastric cancer cells.
23254963 2013 Elevated expression of MAC30 predicts lymph node metastasis and unfavorable prognosis in patients with epithelial ovarian cancer.
23229099 2013 Overexpression of MAC30 is associated with poor clinical outcome in human non-small-cell lung cancer.
22024687 2011 Significance of mRNA and protein expression of MAC30 in progression of colorectal cancer.
21269460 2011 Initial characterization of the human central proteome.