Property Summary

NCBI Gene PubMed Count 12
Grant Count 21
R01 Count 15
Funding $2,662,599.01
PubMed Score 300.65
PubTator Score 25.77

Knowledge Summary

Patent

No data available

Gene RIF (8)

PMID Text
24390475 Shadoo is degraded in Scrapie-infected rodents and cultured cells mediated by proteasome degradation after modification by ubiquitination.
21257747 a conserved physiological activity between PrP(C) and Sho to protect cells from stress-induced toxicity and suggests that Sho and PrP(C) might act on similar signaling pathways.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
18805828 Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease
18805828 Observational study of gene-disease association. (HuGE Navigator)
18778261 A novel solid phase technology for high- throughput synthesis of the SPRN gene is reported.

AA Sequence

MNWAPATCWALLLAAAFLCDSGAAKGGRGGARGSARGGVRGGARGASRVRVRPAQRYGAPGSSLRVAAAG      1 - 70
AAAGAAAGAAAGLAAGSGWRRAAGPGERGLEDEEDGVPGGNGTGPGIYSYRAWTSGAGPTRGPRLCLVLG     71 - 140
GALGALGLLRP                                                               141 - 151
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Publication (14)

PMID Year Title
24390475 2014 Disruption of glycosylation enhances ubiquitin-mediated proteasomal degradation of Shadoo in Scrapie-infected rodents and cultured cells.
21257747 2011 Conserved stress-protective activity between prion protein and Shadoo.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
18805828 2008 Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease.
18778261 2008 A novel solid phase technology for high-throughput gene synthesis.
17199895 2007 Comparative genomic analysis of prion genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15342797 2004 Evolution of vertebrate genes related to prion and Shadoo proteins--clues from comparative genomic analysis.
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