Protein Summary
Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi. The protein encoded by this gene can function as a guanine nucleotide exchange factor (GEF) and may play a role in intracellular signaling and cytoskeleton dynamics at the Golgi apparatus. Polymorphisms in the region of this gene have been found to be associated with spinocerebellar ataxia in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
- ENST00000360461
- ENSP00000353646
- ENSG00000196155
- ENST00000379344
- ENSP00000368649
- ENST00000393966
- ENSP00000462601
- ENST00000427155
- ENSP00000401118
- ENST00000450733
- ENSP00000398030
- ENST00000563969
- ENSP00000457086
- PRTPHN1
- SCA4
- PRTPHN1
- ARHGEF44
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor | 0.79 | ||
tissue sample | 0.64 | ||
transcription factor binding site profile | 0.6 | ||
protein domain | 0.58 | ||
tissue | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 108.08 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 85 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 108.08 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 85 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0