Property Summary

NCBI Gene PubMed Count 21
PubMed Score 56.24
PubTator Score 35.73

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
non-small cell lung cancer 2798 8.10599841848379E-25
lung carcinoma 2844 1.76674187768709E-21
ependymoma 2514 1.25479275752473E-10
lung adenocarcinoma 2714 2.4900621679335E-10
glioblastoma 5572 2.27068440310279E-8
pituitary cancer 1972 2.79491468858825E-8
group 4 medulloblastoma 1875 3.86272793521521E-8
pediatric high grade glioma 2712 8.50087863940854E-8
adrenocortical carcinoma 1427 1.65789417222993E-7
ovarian cancer 8492 1.89937380384012E-7
lung cancer 4473 7.60394337101412E-7
permanent atrial fibrillation 44 2.73166444562254E-6
malignant mesothelioma 3163 3.14624147463493E-6
tuberculosis 1563 5.09353515074428E-6
atypical teratoid / rhabdoid tumor 4369 5.19129226798005E-6
breast carcinoma 1614 1.03899326201267E-5
pilocytic astrocytoma 3086 3.1973944849857E-5
Duchenne muscular dystrophy 602 5.4400355922631E-5
cystic fibrosis 1670 7.09666877415822E-5
fascioscapulohumeral muscular dystrophy 100 1.8366304479189E-4
invasive ductal carcinoma 2950 3.33836176329792E-4
primary pancreatic ductal adenocarcinoma 1271 3.9678759431525E-4
Atopic dermatitis 944 4.20574183623169E-4
ductal carcinoma in situ 1745 7.62443079835267E-4
acute quadriplegic myopathy 1157 9.03692178761622E-4
medulloblastoma, large-cell 6234 0.00133583588629295
limb girdle muscular dystrophy 2A 156 0.00170758531506778
Breast cancer 3099 0.00231578781837892
pancreatic cancer 2300 0.00232286936932365
cutaneous lupus erythematosus 1056 0.00296338010060378
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.00379760962582164
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0128214202759898
psoriasis 6685 0.0151753666071261
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0253591227609748
active ulcerative colitis 477 0.030400292601155
Disease Target Count Z-score Confidence
Hemochromatosis 55 5.117 2.6
Anemia 252 3.907 2.0
Siderosis 9 3.162 1.6



Accession Q53TN4 B2RE79 B4DWD7 Q6KC16 Q6KC17 Q6P147 Q6ZR51 Q9H0Q8 Q9H5G5
Symbols DCYTB


PANTHER Protein Class (2)

  Ortholog (11)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum OMA EggNOG
Anole lizard OMA EggNOG
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA EggNOG Inparanoid

 IMPC Term (1)

Gene RIF (12)

23012398 Letter: report mutations in CYBRD1 promoter in and possible role in iron hemostasis in patients with porphyria cutanea tarda.
22773607 Polymorphisms in CYBRD1 modulates iron phenotype in HFE p.C282Y homozygous hemochromatosis.
20587610 Observational study of gene-disease association. (HuGE Navigator)
19673882 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19023099 Observational study of gene-disease association. (HuGE Navigator)
18492824 The results of this study confirm that Dcytb can act as a ferric reductase that stimulates iron uptake in Caco-2 cells.
18194661 Functional characterization of Cybrd1 heme groups and iron/ascorbate metabolism.
18092813 The current study concerns the recombinant expression, purification, and initial spectroscopic characterization of a recombinant form of the human ferric reductase.
17975119 Observational study of gene-disease association. (HuGE Navigator)
17068337 Duodenal cytochrome b present in human erythrocytes may contribute to their ability to reduce extracellular monodehydroascorbate.

AA Sequence

GQRSTM                                                                    281 - 286

Text Mined References (35)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23012398 2013 Iron homeostasis in porphyria cutanea tarda: mutation analysis of promoter regions of CP, CYBRD1, HAMP and SLC40A1.
22773607 2012 CYBRD1 as a modifier gene that modulates iron phenotype in HFE p.C282Y homozygous patients.
21516116 2011 Next-generation sequencing to generate interactome datasets.
20587610 2010 Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19673882 2009 A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis.
19369195 2009 Large-scale proteomics analysis of the human kinome.