| Tbio | EARP-interacting protein |
This gene has been reported in PMID 9403053 as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene resides on chromosome 2 rather than chromosome 11. [provided by RefSeq, Dec 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Substance-Related Disorders | 115 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 5112 | 4.3e-06 |
| ovarian cancer | 8520 | 8.5e-06 |
| invasive ductal carcinoma | 2951 | 8.1e-04 |
| lung cancer | 4740 | 1.7e-03 |
| psoriasis | 6694 | 1.9e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Endophthalmitis | 12 | 3.563 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | -1.100 | 4.3e-06 |
| invasive ductal carcinoma | 1.100 | 8.1e-04 |
| lung cancer | 1.300 | 1.7e-03 |
| ovarian cancer | 1.200 | 8.5e-06 |
| psoriasis | 1.100 | 1.9e-03 |
MEDDAPVIYGLEFQARALTPQTAETDAIRFLVGTQSLKYDNQIHIIDFDDENNIINKNVLLHQAGEIWHI 1 - 70 SASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELESGSHESPDDSSSTAQTLELLCHLDNTAHGNMACV 71 - 140 VWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEGKGQLKFTSGRWSPHHNCTQVATANDTTLR 141 - 210 GWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRY 211 - 280 NHSHDQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQEDHRSEEKSKEPLQDNVIATYEEHEDSV 281 - 350 YAVDWSSADPWLFASLSYDGRLVINRVPRALKYHILL 351 - 387 //
