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Tbio Protein TSSC1

This gene has been reported in PMID 9403053 as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene resides on chromosome 2 rather than chromosome 11. [provided by RefSeq, Dec 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 9
PubMed Score 4.60
PubTator Score 2.54

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count
Substance-Related Disorders 114
Disease Target Count P-value
atypical teratoid / rhabdoid tumor 4369 4.2658328792695E-6
ovarian cancer 8492 8.45886936901367E-6
invasive ductal carcinoma 2950 8.07720275211174E-4
lung cancer 4473 0.0016710875308118
psoriasis 6685 0.00185619896911075
Disease Target Count Z-score Confidence
adrenocortical carcinoma 1427 3.116 1.6

Expression

  Differential Expression (5)

Disease log2 FC p
psoriasis 1.100 0.002
atypical teratoid / rhabdoid tumor -1.100 0.000
lung cancer 1.300 0.002
invasive ductal carcinoma 1.100 0.001
ovarian cancer 1.200 0.000

Synonym

Accession Q53HC9 D6W4Y1 O43179 Q53S19 Q53SG2
Symbols EIPR1

Gene

TSSC1

 Compartment GO Term (6)

 HCA RNA Cell Line (56)

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 UniProt Keyword (6)

Gene RIF (1)

PMID Text
23933319 TSSC1 inhibits breast cancer cell invasion. Subsequently, TSSC1 is confirmed as a target of Runx2 and is negatively regulated by Runx2.

AA Sequence 

MEDDAPVIYGLEFQARALTPQTAETDAIRFLVGTQSLKYDNQIHIIDFDDENNIINKNVLLHQAGEIWHI      1 - 70
SASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELESGSHESPDDSSSTAQTLELLCHLDNTAHGNMACV     71 - 140
VWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEGKGQLKFTSGRWSPHHNCTQVATANDTTLR    141 - 210
GWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRY    211 - 280
NHSHDQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQEDHRSEEKSKEPLQDNVIATYEEHEDSV    281 - 350
YAVDWSSADPWLFASLSYDGRLVINRVPRALKYHILL                                     351 - 387
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Text Mined References (12)

PMID Year Title
23933319 2013 Runx2 induces bone osteolysis by transcriptional suppression of TSSC1.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
21269460 2011 Initial characterization of the human central proteome.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
17353931 2007 Large-scale mapping of human protein-protein interactions by mass spectrometry.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15815621 2005 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
9925925 1998 Subchromosomal assignment1 of the TSSC1 gene to human chromosome band 11p15.5 near the HBB gene cluster.
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