Tbio | Protein TSSC1 |
This gene has been reported in PMID 9403053 as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene resides on chromosome 2 rather than chromosome 11. [provided by RefSeq, Dec 2008]
Comments
Disease | Target Count |
---|---|
Substance-Related Disorders | 114 |
Disease | Target Count | P-value |
---|---|---|
atypical teratoid / rhabdoid tumor | 4369 | 4.2658328792695E-6 |
ovarian cancer | 8492 | 8.45886936901367E-6 |
invasive ductal carcinoma | 2950 | 8.07720275211174E-4 |
lung cancer | 4473 | 0.0016710875308118 |
psoriasis | 6685 | 0.00185619896911075 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
adrenocortical carcinoma | 1427 | 3.116 | 1.6 |
Disease | log2 FC | p |
---|---|---|
psoriasis | 1.100 | 0.002 |
atypical teratoid / rhabdoid tumor | -1.100 | 0.000 |
lung cancer | 1.300 | 0.002 |
invasive ductal carcinoma | 1.100 | 0.001 |
ovarian cancer | 1.200 | 0.000 |
PMID | Text |
---|---|
23933319 | TSSC1 inhibits breast cancer cell invasion. Subsequently, TSSC1 is confirmed as a target of Runx2 and is negatively regulated by Runx2. |
MEDDAPVIYGLEFQARALTPQTAETDAIRFLVGTQSLKYDNQIHIIDFDDENNIINKNVLLHQAGEIWHI 1 - 70 SASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELESGSHESPDDSSSTAQTLELLCHLDNTAHGNMACV 71 - 140 VWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEGKGQLKFTSGRWSPHHNCTQVATANDTTLR 141 - 210 GWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRY 211 - 280 NHSHDQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQEDHRSEEKSKEPLQDNVIATYEEHEDSV 281 - 350 YAVDWSSADPWLFASLSYDGRLVINRVPRALKYHILL 351 - 387 //
PMID | Year | Title |
---|---|---|
23933319 | 2013 | Runx2 induces bone osteolysis by transcriptional suppression of TSSC1. |
22814378 | 2012 | N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. |
21269460 | 2011 | Initial characterization of the human central proteome. |
19690332 | 2009 | Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. |
17353931 | 2007 | Large-scale mapping of human protein-protein interactions by mass spectrometry. |
16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
15815621 | 2005 | Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
9925925 | 1998 | Subchromosomal assignment1 of the TSSC1 gene to human chromosome band 11p15.5 near the HBB gene cluster. |
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