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Tbio Pyrroline-5-carboxylate reductase 3

Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline.

This gene encodes a protein that belongs to the pyrroline-5-carboxylate reductase family of enzymes. Members of this family catalyze the final step in proline biosynthesis, converting pyrroline-5-carboxylate to proline. Glutamate and ornithine are precursors in the synthesis of proline. The protein encoded by this gene is a cytoplasmic enzyme involved in the biosynthesis of proline from ornithine. [provided by RefSeq, Aug 2016]

 Comments

Property Summary

NCBI Gene PubMed Count 10
PubMed Score 0.58
PubTator Score 0.42

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (6)

Disease Z-score Confidence
Cutis laxa 28 3.85 1.9
invasive ductal carcinoma 2,950
lung adenocarcinoma 2,713
non-inflammatory breast cancer 208
non-small cell lung cancer 2,798
psoriasis 6,685

Expression

  Differential Expression (5)

Disease log2 FC p
psoriasis 1.500 0.000
non-small cell lung cancer 1.140 0.000
lung adenocarcinoma 1.500 0.000
non-inflammatory breast cancer 1.100 0.020
invasive ductal carcinoma 1.300 0.004

Synonym

Accession Q53H96 B3KMB5 B4DVT6 H0Y6C3 Q8N3N9 Q96HX4 Q9H896 P5C reductase 3
Symbols PYCR3

Gene

PYCRL

 GO Function (1)

 GO Component (1)

 GO Process (2)

 Compartment GO Term (8)

Pathway (12)

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 UniProt Keyword (10)

Gene RIF (1)

PMID Text
18854154 Knockdown of pyrroline-5-carboxylate reductase-like (PYCRL) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1

AA Sequence 

MAAAEPSPRRVGFVGAGRMAGAIAQGLIRAGKVEAQHILASAPTDRNLCHFQALGCRTTHSNQEVLQSCL      1 - 70
LVIFATKPHVLPAVLAEVAPVVTTEHILVSVAAGVSLSTLEELLPPNTRVLRVLPNLPCVVQEGAIVMAR     71 - 140
GRHVGSSETKLLQHLLEACGRCEEVPEAYVDIHTGLSGSGVAFVCAFSEALAEGAVKMGMPSSLAHRIAA    141 - 210
QTLLGTAKMLLHEGQHPAQLRSDVCTPGGTTIYGLHALEQGGLRAATMSAVEAATCRAKELSRK          211 - 274
//

Text Mined References (15)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
23585552 2013 Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment.
23024808 2012 Functional specialization in proline biosynthesis of melanoma.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
21269460 2011 Initial characterization of the human central proteome.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
16421571 2006 DNA sequence and analysis of human chromosome 8.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
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