| Tbio | Pyrroline-5-carboxylate reductase 3 |
Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline.
This gene encodes a protein that belongs to the pyrroline-5-carboxylate reductase family of enzymes. Members of this family catalyze the final step in proline biosynthesis, converting pyrroline-5-carboxylate to proline. Glutamate and ornithine are precursors in the synthesis of proline. The protein encoded by this gene is a cytoplasmic enzyme involved in the biosynthesis of proline from ornithine. [provided by RefSeq, Aug 2016]
This gene encodes a protein that belongs to the pyrroline-5-carboxylate reductase family of enzymes. Members of this family catalyze the final step in proline biosynthesis, converting pyrroline-5-carboxylate to proline. Glutamate and ornithine are precursors in the synthesis of proline. The protein encoded by this gene is a cytoplasmic enzyme involved in the biosynthesis of proline from ornithine. [provided by RefSeq, Aug 2016]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 1.0e-16 |
| lung adenocarcinoma | 2716 | 1.3e-11 |
| Breast cancer | 3578 | 2.9e-11 |
| psoriasis | 6694 | 3.1e-04 |
| invasive ductal carcinoma | 2951 | 4.4e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cutis Laxa | 39 | 3.846 | 1.9 |
| Disease | log2 FC | p |
|---|---|---|
| Breast cancer | 1.100 | 2.9e-11 |
| invasive ductal carcinoma | 1.300 | 4.4e-03 |
| lung adenocarcinoma | 1.500 | 1.3e-11 |
| non-small cell lung cancer | 1.140 | 1.0e-16 |
| psoriasis | 1.500 | 3.1e-04 |
MAAAEPSPRRVGFVGAGRMAGAIAQGLIRAGKVEAQHILASAPTDRNLCHFQALGCRTTHSNQEVLQSCL 1 - 70 LVIFATKPHVLPAVLAEVAPVVTTEHILVSVAAGVSLSTLEELLPPNTRVLRVLPNLPCVVQEGAIVMAR 71 - 140 GRHVGSSETKLLQHLLEACGRCEEVPEAYVDIHTGLSGSGVAFVCAFSEALAEGAVKMGMPSSLAHRIAA 141 - 210 QTLLGTAKMLLHEGQHPAQLRSDVCTPGGTTIYGLHALEQGGLRAATMSAVEAATCRAKELSRK 211 - 274 //
