| Tbio | Kelch-like protein 22 |
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.
Comments
| Disease | Z-score | Confidence |
|---|---|---|
| Hepatoblastoma 17 | 3.453 | 1.7 |
| malignant mesothelioma 3,162 | ||
| medulloblastoma, large-cell 6,234 | ||
| psoriasis 6,685 |
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | 1.300 | 0.000 |
| psoriasis | -1.200 | 0.001 |
| medulloblastoma, large-cell | -1.400 | 0.005 |
| PMID | Text |
|---|---|
| 24067371 | CUL3/KLHL22 may contact two distinct motifs within PLK1 protein, consistent with the bivalent mode of substrate targeting. |
MAEEQEFTQLCKLPAQPSHPHCVNNTYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAA 1 - 70 SCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCC 71 - 140 DFLMSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCE 141 - 210 TEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDKLDPSPLRDTVASALMYHRNE 211 - 280 SLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNF 281 - 350 VYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYD 351 - 420 PATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMAT 421 - 490 LLNKLYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRT 491 - 560 GYVHIYDVEKDCWEEGPQLDNSISGLAACVLTLPRSLLLEPPRGTPDRSQADPDFASEVMSVSDWEEFDN 561 - 630 SSED 631 - 634 //
| PMID | Year | Title |
|---|---|---|
| 24067371 | 2013 | CUL3 and protein kinases: insights from PLK1/KLHL22 interaction. |
| 23676014 | 2013 | Update on the Kelch-like (KLHL) gene family. |
| 23455478 | 2013 | Ubiquitylation-dependent localization of PLK1 in mitosis. |
| 23393555 | 2013 | Genome-wide association study of retinopathy in individuals without diabetes. |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 22223895 | 2012 | Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-?-acetylation features. |
| 19995937 | 2009 | The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 15461802 | 2004 | A genome annotation-driven approach to cloning the human ORFeome. |
| More... |
