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Tbio Kelch-like protein 22

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.

 Comments

Property Summary

NCBI Gene PubMed Count 11
PubMed Score 1.11
PubTator Score 2.41

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count P-value
malignant mesothelioma 3232 1.7e-06
psoriasis 6694 1.1e-03
medulloblastoma, large-cell 6241 5.5e-03
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.5
Disease Target Count Z-score Confidence
Hepatoblastoma 19 3.457 1.7

Expression

  Differential Expression (3)

Disease log2 FC p
malignant mesothelioma 1.300 1.7e-06
medulloblastoma, large-cell -1.400 5.5e-03
psoriasis -1.200 1.1e-03

Synonym

Accession Q53GT1 A8K3Q4 A8MTV3 B7Z2G1 D3DX30 Q96B68 Q96KC6
Symbols KELCHL

Gene

KLHL22

  Ortholog (13)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG

 UniProt Keyword (14)

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 GO Component (6)

 GO Process (5)

 Compartment GO Term (35)

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 GWAS Trait (1)

 HCA RNA Cell Line (56)

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Pathway (8)

Protein-protein Interaction (26)

SCARF2   ATG4C   GLUD2   GLUD1   KLHL13   KLHL9   NDUFB9   NIPSNAP2   METTL15   LYRM4   TRMT6   MICU1   NOA1   NUDCD3   NDUFAF5   NFS1   ZBTB33   FMC1   LYRM7   KLHL26   ZBTB34   TMEM223   CIZ1   SCAF8   EMC7   GFER  

Gene RIF (1)

AA Sequence 

MAEEQEFTQLCKLPAQPSHPHCVNNTYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAA      1 - 70
SCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCC     71 - 140
DFLMSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCE    141 - 210
TEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDKLDPSPLRDTVASALMYHRNE    211 - 280
SLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNF    281 - 350
VYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYD    351 - 420
PATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMAT    421 - 490
LLNKLYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRT    491 - 560
GYVHIYDVEKDCWEEGPQLDNSISGLAACVLTLPRSLLLEPPRGTPDRSQADPDFASEVMSVSDWEEFDN    561 - 630
SSED                                                                      631 - 634
//

Text Mined References (15)

PMID Year Title