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Tbio
SLC44A4
Choline transporter-like protein 4

Protein Summary
Description
Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity) (PubMed:23651124, PubMed:28013291). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (PubMed:24379411). Isoform 3: Has also thiamine pyrophosphate transporter activity. The protein encoded by this gene may be a sodium-dependent transmembrane transport protein involved in the uptake of choline by cholinergic neurons. Defects in this gene can cause sialidosis, a lysosomal storage disease. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229729
  • ENSP00000229729
  • ENSG00000204385
  • ENST00000375562
  • ENSP00000364712
  • ENST00000383379
  • ENSP00000372870
  • ENSG00000206378
  • ENST00000415517
  • ENSP00000414120
  • ENSG00000229077
  • ENST00000417894
  • ENSP00000389244
  • ENSG00000235336
  • ENST00000425238
  • ENSP00000399161
  • ENSG00000228263
  • ENST00000442152
  • ENSP00000398852
  • ENSG00000232180
  • ENST00000453831
  • ENSP00000393939
  • ENSG00000231479
  • ENST00000544672
  • ENSP00000444109
  • ENST00000546461
  • ENSP00000449039
  • ENST00000547493
  • ENSP00000449232
  • ENST00000547684
  • ENSP00000449180
  • ENST00000548188
  • ENSP00000447560
  • ENST00000549663
  • ENSP00000449642
  • ENST00000549677
  • ENSP00000449518
  • ENST00000550401
  • ENSP00000448474
  • ENST00000551168
  • ENSP00000448088
  • ENST00000553121
  • ENSP00000447704
  • ENST00000644409
  • ENSP00000496109

Symbol
  • C6orf29
  • CTL4
  • NG22
  • TPPT1
  • CTL4
  • NG22
  • TPPT
  • DFNA72
  • hTPPT1
  • C6orf29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
phenotype
0.73
disease
0.65
biological process
0.62
cell line
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.75   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 52   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.75   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0