Property Summary

NCBI Gene PubMed Count 15
PubMed Score 14.33
PubTator Score 3.61

Knowledge Summary

Patent (3,622)

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
lung adenocarcinoma 2714 2.50444291972276E-14
non-small cell lung cancer 2798 2.68355485766285E-10
ovarian cancer 8492 5.34938910628012E-7
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00118377281782798
atypical teratoid / rhabdoid tumor 4369 0.00122534231206809
ductal carcinoma in situ 1745 0.00177953467092364
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00231052619374302
breast carcinoma 1614 0.00732360025123673
group 3 medulloblastoma 2254 0.0095878946135606
primary pancreatic ductal adenocarcinoma 1271 0.0106897005811981
ulcerative colitis 2087 0.0114022014028688
pancreatic cancer 2300 0.0191459021166991
gastric carcinoma 832 0.0336290038989451
fibroadenoma 557 0.0399257374308117
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0428678971371469
invasive ductal carcinoma 2950 0.0433653425933549
Disease Target Count Z-score Confidence
Osteoporosis 259 0.0 2.0

Expression

Synonym

Accession Q504Y2 D6W5A0 Q96I09
Symbols Vlk
SGK493

Gene

  Ortholog (8)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG
Platypus EggNOG Inparanoid
Xenopus OMA EggNOG

 GWAS Trait (1)

Pathway (1)

Gene RIF (5)

PMID Text
25862977 The Fam20C-and VLK-family of kinases mediate the phosphorylation of proteins in the secretory pathway and extracellular space.Mutation in several secretory pathway kinases cause human disease
25171405 VLK is rapidly and quantitatively secreted from platelets in response to stimuli and can tyrosine phosphorylate coreleased proteins utilizing endogenous as well as exogenous ATP sources.
24407380 our results suggest that genes CA10 and also SGK493 may be an important risk factor for asthma development, especially for a nonatopic phenotype.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19961619 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)

AA Sequence

MRRRRAAVAAGFCASFLLGSVLNVLFAPGSEPPRPGQSPEPSPAPGPGRRGGRGELARQIRARYEEVQRY      1 - 70
SRGGPGPGAGRPERRRLMDLAPGGPGLPRPRPPWARPLSDGAPGWPPAPGPGSPGPGPRLGCAALRNVSG     71 - 140
AQYMGSGYTKAVYRVRLPGGAAVALKAVDFSGHDLGSCVREFGVRRGCYRLAAHKLLKEMVLLERLRHPN    141 - 210
VLQLYGYCYQDSEDIPDTLTTITELGAPVEMIQLLQTSWEDRFRICLSLGRLLHHLAHSPLGSVTLLDFR    211 - 280
PRQFVLVDGELKVTDLDDARVEETPCAGSTDCILEFPARNFTLPCSAQGWCEGMNEKRNLYNAYRFFFTY    281 - 350
LLPHSAPPSLRPLLDSIVNATGELAWGVDETLAQLEKVLHLYRSGQYLQNSTASSSTEYQCIPDSTIPQE    351 - 420
DYRCWPSYHHGSCLLSVFNLAEAVDVCESHAQCRAFVVTNQTTWTGRQLVFFKTGWSQVVPDPNKTTYVK    421 - 490
ASG                                                                       491 - 493
//

Text Mined References (16)

PMID Year Title
25862977 2015 The secretory pathway kinases.
25171405 2014 A secreted tyrosine kinase acts in the extracellular environment.
25108383 2014 Genome-wide association analyses identify variants in developmental genes associated with hypospadias.
24407380 2014 Polymorphisms in recent GWA identified asthma genes CA10, SGK493, and CTNNA3 are associated with disease severity and treatment response in childhood asthma.
22504420 2012 Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19961619 2009 A pooling-based genome-wide analysis identifies new potential candidate genes for atopy in the European Community Respiratory Health Survey (ECRHS).
19465597 2009 The novel protein kinase Vlk is essential for stromal function of mesenchymal cells.
19097194 2009 Short limbs, cleft palate, and delayed formation of flat proliferative chondrocytes in mice with targeted disruption of a putative protein kinase gene, Pkdcc (AW548124).
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
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