Protein Summary
Has antibacterial activity. Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 8p23. [provided by RefSeq, Nov 2014]
- ENST00000382205
- ENSP00000371640
- ENSG00000205882
- ENST00000526438
- ENSP00000435010
- ENST00000645046
- ENSP00000494837
- ENSG00000284754
- ENST00000646417
- ENSP00000495848
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
tissue | 0.47 | ||
biological term | 0.33 | ||
pathway | 0.32 | ||
cell line | 0.31 | ||
disease | 0.29 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.94 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 7 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.94 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 7 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0