AASDH
Beta-alanine-activating enzyme
Protein Summary
Covalently binds beta-alanine in an ATP-dependent manner to form a thioester bond with its phosphopantetheine group and transfers it to an, as yet, unknown acceptor. May be required for a post-translational protein modification or for post-transcriptional modification of an RNA. This gene encodes a member of the non-ribosome peptide syntesase (NRPS) enzyme family. The encoded protein contains an AMP-binding domain, PP-binding (phosphopantetheine, or pantetheine 4'phosphate-binding) domain and the Pyrrolo-quinoline quinon (PQQ) binding domain. The protein is expressed in several adult tissues. [provided by RefSeq, Apr 2016]
- ENST00000205214
- ENSP00000205214
- ENSG00000157426
- ENST00000451613
- ENSP00000409656
- ENST00000502617
- ENSP00000421171
- ENST00000513376
- ENSP00000423760
- ACSF4
- U26
- LYS2
- ACSF4
- NRPS998
- NRPS1098
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.99 | ||
virus perturbation | 0.92 | ||
cellular component | 0.9 | ||
histone modification site profile | 0.89 | ||
protein domain | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.24 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 54 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.24 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 54 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0