Tbio CERKL Ceramide kinase-like protein

Protein Summary

Description

Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions. This gene was initially identified as a locus (RP26) associated with an autosomal recessive form of retinitis pigmentosa (arRP) disease. This gene encodes a protein with ceramide kinase-like domains, however, the protein does not phosphorylate ceramide and its target substrate is currently unknown. This protein may be a negative regulator of apoptosis in photoreceptor cells. Mutations in this gene cause a form of retinitis pigmentosa characterized by autosomal recessive cone and rod dystrophy (arCRD). Alternative splicing of this gene results in multiple transcript variants encoding different isoforms and non-coding transcripts.[provided by RefSeq, May 2010]

Uniprot Accession IDs

• Q49MI3
• B2RPL2
• B4DEY1
• Q49MH9
• Q49MI0
• Q49MI1
• Q49MI2
• Q5DVJ2
• Q5DVJ4
• Q5DVJ5
• Q6UZF6
• Q6ZP59

Gene Name

• CERKL

Ensembl ID

• ENST00000339098
• ENSP00000341159
• ENSG00000188452
• ENST00000374967
• ENSP00000364106
• ENST00000374969
• ENSP00000364108
• ENST00000374970
• ENSP00000364109
• ENST00000409440
• ENSP00000387080
• ENST00000410087
• ENSP00000386725
• ENST00000421817
• ENSP00000411466
• ENST00000452174
• ENSP00000409198

Symbol

• RP26

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.67
tissue sample	0.65
cell type or tissue	0.6
cellular component	0.6
microRNA	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.33   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 145   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.33   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0