Tchem PARP15 Poly [ADP-ribose] polymerase 15

Protein Summary

Description

Possesses ADP-ribosyltransferase activity (PubMed:16061477, PubMed:25635049). Transcriptional repressor (PubMed:16061477). PARP15 is a macrodomain-containing transcriptional repressor with poly(ADP-ribose) polymerase activity (Aguiar et al., 2005 [PubMed 16061477]).[supplied by OMIM, May 2008]

Uniprot Accession IDs

• Q460N3
• J3KR47
• Q8N1K3
• PARP-15

Gene Name

• PARP15

Ensembl ID

• ENST00000310366
• ENSP00000308436
• ENSG00000173200
• ENST00000464300
• ENSP00000417214

Symbol

• BAL3
• BAL3
• ARTD7
• pART7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.58
cell type or tissue	0.56
histone modification site profile	0.52
tissue sample	0.47
trait	0.46

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.04   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 27   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.04   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0