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Tbio
RABL6
Rab-like protein 6

Protein Summary
Description
May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. This gene encodes a member of the Ras superfamily of small GTPases. The encoded protein binds to both GTP and GDP and may play a role in cell growth and survival. Overexpression of this gene may play a role in breast cancer tumorigenesis, and pseudogenes of this gene are located on the long arm of chromosome 2 and the short arm of chromosome 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311502
  • ENSP00000311134
  • ENSG00000196642
  • ENST00000357466
  • ENSP00000350056
  • ENST00000371663
  • ENSP00000360727
  • ENST00000371671
  • ENSP00000360736

Symbol
  • C9orf86
  • PARF
  • PARF
  • RBEL1
  • pp8875
  • C9orf86
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
interacting protein
0.84
kinase perturbation
0.81
molecular function
0.76
tissue sample
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.82   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.82   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0