Tbio MGAT5B Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

Protein Summary

Description

Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAc-beta1,2-Man-alpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAc-beta1,2-Man-alpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway. The MGAT5B gene encodes a beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.155) that functions in the synthesis of complex cell surface N-glycans (Kaneko et al., 2003 [PubMed 14623122]).[supplied by OMIM, Nov 2008]

Uniprot Accession IDs

• Q3V5L5
• Q6P3S8
• Q6P6B3
• Q766X5
• Q76D04
• Q96LS2

Gene Name

• MGAT5B

Ensembl ID

• ENST00000301618
• ENSP00000301618
• ENSG00000167889
• ENST00000428789
• ENSP00000391227
• ENST00000569840
• ENSP00000456037

Symbol

• KIAA2008
• GnT-IX
• GnT-VB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.72
transcription factor	0.7
tissue sample	0.62
virus perturbation	0.59
histone modification site profile	0.55

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Alpha-1,6-mannosylglycoprotein 6-beta-n-acetylglucosaminyltransferase B

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Alpha-1,6-mannosylglycoprotein 6-beta-n-acetylglucosaminyltransferase B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.77   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 51   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.77   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0