| Tdark | Erythroid differentiation-related factor 1 |
Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene.
This gene may play a role in erythroid cell differentiation. The encoded protein inhibits DNA binding of the erythroid transcription factor GATA-1 and may regulate the expression of alpha-globin and gamma-globin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
This gene may play a role in erythroid cell differentiation. The encoded protein inhibits DNA binding of the erythroid transcription factor GATA-1 and may regulate the expression of alpha-globin and gamma-globin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| juvenile dermatomyositis | 1189 | 5.54708209090061E-11 |
| malignant mesothelioma | 3163 | 2.12201955545813E-6 |
| tuberculosis and treatment for 6 months | 686 | 3.90022181450988E-5 |
| ovarian cancer | 8492 | 0.00126512123721657 |
| dermatomyositis | 967 | 0.00185336592954894 |
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | 1.200 | 0.000 |
| juvenile dermatomyositis | 1.047 | 0.000 |
| tuberculosis and treatment for 6 months | 1.600 | 0.000 |
| ovarian cancer | 1.500 | 0.001 |
| dermatomyositis | 1.100 | 0.002 |
MGDAKEAGAEGPPAGAAARGGLSLLSQGESEESSAQGSALFLGGNEVKSRAVVKYSSAPPRTAFARLEEK 1 - 70 TDLKLPPANWLRESAKLGPAGTTILGNSKKSKPFSSFGMAYDFIDSVGNDVDVVSDSENIKKLLKIPYSK 71 - 140 SHVSMAVHRIGRTLLLDELDIQELFMRSSQTGDWTWLKEFYQRLIDQKWQRKKKSKEHWYQKAILSKFLY 141 - 210 YSINGDGAAQPVSSTAEQQESSSSDQTNDSEGASWPAPFEMPSSVSEDPSASSQGSEPLEPSYIVGHVAS 211 - 280 APKEQNLITLFNDGEHSQGLKNDFVRNILWTFEDIHMLVGSNMPIFGGGRYPAVSLRLRDNNKPINVLTG 281 - 350 IDYWLDNLICNVPELVMCFHVNGIVQKYEMIKTEEIPNLENSNFSTKVIKDIAQNILSFLKSNCTKEGHT 351 - 420 YWLFKASGSDIVKLYDLTTLCEETEDKYQNPFTMPVAILLYKVACNMMMKKNQNKKHYGTIRTLLLNCLK 421 - 490 LLDKSRHPQIIASANYMLSELFQLDEPKKEENSESPLNENSDESYSEEEEEMPDSDENGSYSTSSDPSDD 491 - 560 SKAVAIIKSVGELSVPEKYKSIHQIRPSCAFPVCHDTEERCRLVLSYVLEGLKSVDSSIKKESDLPAADP 561 - 630 STPIPLKYEDESSRGGPEGLEKQMALFLDKMGSLQKGNYSSQSGMIPGSWQHKMKLQLILKSSKAYYVLS 631 - 700 DAAMSLQKYGRALRYIKLALQSHDTYCCLCTNMLSEVLLFLSQYLTLCGDIQLMLAQNANNRAAHLEEFH 701 - 770 YQTKEDQEILHSLHRESSCQGFAWATDLSTDLESQLSVSCKCYEAANEILQFSDLKSQNPEHYVQVLKRM 771 - 840 GNIRNEIGVFYMNQAAALQSERLVSKSVSAAEQQLWKKSFSCFEKGIHNFESIEDATNAALLLCNTGRLM 841 - 910 RICAQAHCGAGDELKREFSPEEGLYYNKAIDYYLKALRSLGTRDIHPAVWDSVNWELSTTYFTMATLQQD 911 - 980 YAPLSRKAQEQIEKEVSEAMMKSLKYCDVDSVSARQPLCQYRAATIHHRLASMYHSCLRNQVGDEHLRKQ 981 - 1050 HRVLADLHYSKAAKLFQLLKDAPCELLRVQLERVAFAEFQMTSQNSNVGKLKTLSGALDIMVRTEHAFQL 1051 - 1120 IQKELIEEFGQPKSGDAAAAADASPSLNREEVMKLLSIFESRLSFLLLQSIKLLSSTKKKTSNNIEDDTI 1121 - 1190 LKTNKHIYSQLLRATANKTATLLERINVIVHLLGQLAAGSAASSNAVQ 1191 - 1238 //
| PMID | Year | Title |
|---|---|---|
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 21269460 | 2011 | Initial characterization of the human central proteome. |
| 20379614 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | |
| 18763094 | 2001 | cDNA cloning and function analysis of two novel erythroid differentiation related genes. |
| 18759052 | 2002 | Antisense EDRF1 gene inhibited GATA-1 transcription factor DNA-binding activity in K562 cells. |
| 18726394 | 2001 | Initial function analysis of a novel erythroid differentiation related gene EDRF1. |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
| 16959974 | 2006 | The consensus coding sequences of human breast and colorectal cancers. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 15164054 | 2004 | The DNA sequence and comparative analysis of human chromosome 10. |
| More... |
