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Tdark Erythroid differentiation-related factor 1

Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene.

This gene may play a role in erythroid cell differentiation. The encoded protein inhibits DNA binding of the erythroid transcription factor GATA-1 and may regulate the expression of alpha-globin and gamma-globin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

 Comments

Property Summary

NCBI Gene PubMed Count 9
PubMed Score 4.21
PubTator Score 6.38

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 1.2
Kidney cancer 2613 0.0 0.7
Disease Target Count Z-score Confidence
Hereditary spherocytosis type 2 18 4.469 2.2

Expression

  Differential Expression (5)

Disease log2 FC p
dermatomyositis 1.100 1.9e-03
juvenile dermatomyositis 1.047 5.5e-11
malignant mesothelioma 1.200 2.1e-06
ovarian cancer -1.400 1.5e-04
tuberculosis and treatment for 6 months 1.600 3.9e-05

Synonym

Accession Q3B7T1 B2RC65 Q3KR40 Q4G190 Q5VZQ4 Q8IZ74 Q9Y3W4
Symbols C10orf137

Gene

EDRF1

  Ortholog (13)

Species Source Disease
OMA EggNOG
OMA EggNOG
OMA EggNOG
OMA EggNOG
OMA EggNOG
OMA EggNOG
OMA EggNOG
OMA EggNOG
OMA EggNOG
Inparanoid EggNOG
OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (10)

 GO Component (1)

 GO Process (2)

 Compartment GO Term (13)

 HCA RNA Cell Line (56)

See all...

Gene RIF (2)

AA Sequence 

MGDAKEAGAEGPPAGAAARGGLSLLSQGESEESSAQGSALFLGGNEVKSRAVVKYSSAPPRTAFARLEEK      1 - 70
TDLKLPPANWLRESAKLGPAGTTILGNSKKSKPFSSFGMAYDFIDSVGNDVDVVSDSENIKKLLKIPYSK     71 - 140
SHVSMAVHRIGRTLLLDELDIQELFMRSSQTGDWTWLKEFYQRLIDQKWQRKKKSKEHWYQKAILSKFLY    141 - 210
YSINGDGAAQPVSSTAEQQESSSSDQTNDSEGASWPAPFEMPSSVSEDPSASSQGSEPLEPSYIVGHVAS    211 - 280
APKEQNLITLFNDGEHSQGLKNDFVRNILWTFEDIHMLVGSNMPIFGGGRYPAVSLRLRDNNKPINVLTG    281 - 350
IDYWLDNLICNVPELVMCFHVNGIVQKYEMIKTEEIPNLENSNFSTKVIKDIAQNILSFLKSNCTKEGHT    351 - 420
YWLFKASGSDIVKLYDLTTLCEETEDKYQNPFTMPVAILLYKVACNMMMKKNQNKKHYGTIRTLLLNCLK    421 - 490
LLDKSRHPQIIASANYMLSELFQLDEPKKEENSESPLNENSDESYSEEEEEMPDSDENGSYSTSSDPSDD    491 - 560
SKAVAIIKSVGELSVPEKYKSIHQIRPSCAFPVCHDTEERCRLVLSYVLEGLKSVDSSIKKESDLPAADP    561 - 630
STPIPLKYEDESSRGGPEGLEKQMALFLDKMGSLQKGNYSSQSGMIPGSWQHKMKLQLILKSSKAYYVLS    631 - 700
DAAMSLQKYGRALRYIKLALQSHDTYCCLCTNMLSEVLLFLSQYLTLCGDIQLMLAQNANNRAAHLEEFH    701 - 770
YQTKEDQEILHSLHRESSCQGFAWATDLSTDLESQLSVSCKCYEAANEILQFSDLKSQNPEHYVQVLKRM    771 - 840
GNIRNEIGVFYMNQAAALQSERLVSKSVSAAEQQLWKKSFSCFEKGIHNFESIEDATNAALLLCNTGRLM    841 - 910
RICAQAHCGAGDELKREFSPEEGLYYNKAIDYYLKALRSLGTRDIHPAVWDSVNWELSTTYFTMATLQQD    911 - 980
YAPLSRKAQEQIEKEVSEAMMKSLKYCDVDSVSARQPLCQYRAATIHHRLASMYHSCLRNQVGDEHLRKQ    981 - 1050
HRVLADLHYSKAAKLFQLLKDAPCELLRVQLERVAFAEFQMTSQNSNVGKLKTLSGALDIMVRTEHAFQL   1051 - 1120
IQKELIEEFGQPKSGDAAAAADASPSLNREEVMKLLSIFESRLSFLLLQSIKLLSSTKKKTSNNIEDDTI   1121 - 1190
LKTNKHIYSQLLRATANKTATLLERINVIVHLLGQLAAGSAASSNAVQ                         1191 - 1238
//

Text Mined References (13)

PMID Year Title