Tchem MYLK3 Myosin light chain kinase 3

Protein Summary

Description

Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008]

Uniprot Accession IDs

• Q32MK0
• B5BUL9
• B7Z5U8
• Q32MK1
• Q96DV1

Gene Name

• MYLK3

Ensembl ID

• ENST00000394809
• ENSP00000378288
• ENSG00000140795
• ENST00000536476
• ENSP00000439297

Symbol

• MLCK
• MLCK
• MLCK2
• caMLCK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.93
protein domain	0.85
gene perturbation	0.76
tissue sample	0.65
biological process	0.64

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Mlck Family / Myosin Light Chain Kinase 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.91   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 246   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.91   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1