Tbio RGS21 Regulator of G-protein signaling 21

Protein Summary

Description

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM, Nov 2008]

Uniprot Accession IDs

• Q2M5E4
• RGS21

Gene Name

• RGS21

Ensembl ID

• ENST00000417209
• ENSP00000428343
• ENSG00000253148

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease	0.51
microRNA	0.49
cell line	0.45
phenotype	0.43
protein complex	0.4

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Regulator Of G-protein Signaling 21

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Regulator Of G-protein Signaling 21

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.99   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 64   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.99   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0