Property Summary

NCBI Gene PubMed Count 29
PubMed Score 15.03
PubTator Score 16.54

Knowledge Summary

Patent (3,434)

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
posterior fossa group A ependymoma 1511 2.39011165776829E-22
pilocytic astrocytoma 3086 7.87892160048417E-14
atypical teratoid / rhabdoid tumor 4369 2.51559502388755E-12
pediatric high grade glioma 2712 2.12838822158181E-10
osteosarcoma 7933 3.45441821809847E-10
glioblastoma 5572 3.71544845342393E-9
medulloblastoma, large-cell 6234 1.26649527061075E-7
medulloblastoma 1524 3.52499385423349E-7
psoriasis 6685 3.32864716141552E-6
ovarian cancer 8492 1.33125867209868E-5
lung cancer 4473 0.00112450246610616
astrocytic glioma 2241 0.00121851799475587
primitive neuroectodermal tumor 3031 0.00418013904334796
progressive supranuclear palsy 674 0.00541094886293346
oligodendroglioma 2849 0.011646328084753
Breast cancer 3099 0.0260219833290876
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0282524227004493
Pick disease 1893 0.0316809798745945
subependymal giant cell astrocytoma 2287 0.0413332292452133
Disease Target Count Z-score Confidence
Necrotizing fasciitis 9 3.52 1.8

Expression

  Differential Expression (19)

Disease log2 FC p
astrocytic glioma -3.200 0.001
posterior fossa group A ependymoma -4.900 0.000
oligodendroglioma -3.100 0.012
psoriasis 3.800 0.000
glioblastoma -4.600 0.000
osteosarcoma 3.701 0.000
medulloblastoma -3.000 0.000
atypical teratoid / rhabdoid tumor -4.800 0.000
medulloblastoma, large-cell -4.100 0.000
primitive neuroectodermal tumor -2.600 0.004
pancreatic ductal adenocarcinoma liver m... 1.116 0.028
lung cancer -1.100 0.001
Breast cancer 2.500 0.026
pediatric high grade glioma -4.200 0.000
pilocytic astrocytoma -4.500 0.000
subependymal giant cell astrocytoma -3.365 0.041
Pick disease -1.400 0.032
progressive supranuclear palsy 1.300 0.005
ovarian cancer 1.700 0.000

Synonym

Accession Q2M2I8 Q4ZFZ3 Q53RX6 Q9UPV4
Symbols

Gene

PDB

4WSQ   5L4Q  

  Ortholog (13)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA Inparanoid
Pig OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA Inparanoid
Zebrafish OMA EggNOG
Fruitfly EggNOG Inparanoid

  TechDev Info (1)

Gary Johnson Kinome profile via MIB/MS Technology

MLP Assay (1)

AID Type Active / Inconclusive / Inactive Description
1982 other 0 / 0 / 0 Kinase inhibition selectivity assay for compound SID-48409448

Gene RIF (8)

PMID Text
25852190 Two of these kinases that were classified as resistors were PX domain-containing serine/threonine kinase (PXK) and AP2-associated kinase 1 (AAK1), which promote receptor endocytosis and may enable cells to resist TRAIL-induced apoptosis
25653444 AAK1 and GAK are critical regulators of HCV entry that function in part by activating EGFR, AP2M1, and NUMB, and as the molecular targets underlying the antiviral effect of sunitinib and erlotinib, respectively.
25496667 Genome-wide shRNA screening identifies AAK1, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells
21464124 AAK1 increases the localization of activated Notch to Rab5-positive endocytic vesicles, while AAK1 depletion or overexpression of Numb, an inhibitor of the pathway, interferes with this localization.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19772629 Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
18976975 Knockdown of AP2 associated kinase 1 (AAK1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells
17494869 These observations suggest that AAK1 functions at multiple steps of the endosomal pathway by regulating transferrin internalization and its rapid recycling back to the plasma membrane from early/sorting endosome.

AA Sequence

MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMK      1 - 70
CALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQ     71 - 140
RLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGV    141 - 210
NAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNS    211 - 280
RYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPK    281 - 350
ARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKP    351 - 420
QAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFY    421 - 490
QQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQ    491 - 560
AALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRA    561 - 630
GHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDD    631 - 700
DNFSKLTAEELLNKDFAKLGEGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGL    701 - 770
PLLSVSDPFIPLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPV    771 - 840
PQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGS    841 - 910
DKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL                       911 - 961
//

Text Mined References (44)

PMID Year Title
25852190 2015 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
25653444 2015 AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets.
25436638 2014 Genetic variants associated with serum thyroid stimulating hormone (TSH) levels in European Americans and African Americans from the eMERGE Network.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23934736 2013 Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22645275 2012 Identification of novel ATP13A2 interactors and their role in ?-synuclein misfolding and toxicity.
21464124 2011 The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
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