Protein Summary
May be involved in transcriptional regulation. This gene encodes a protein containing an N-terminal Kruppel-associated box-containing (KRAB) domain and 13 Kruppel-type C2H2 zinc finger domains. This gene resides on an area of chromosome X that has been implicated in nonsyndromic X-linked cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
- ENST00000409324
- ENSP00000386393
- ENSG00000221994
- ENST00000442455
- ENSP00000393163
- dJ54B20.2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
histone modification site profile | 0.7 | ||
tissue sample | 0.65 | ||
protein domain | 0.58 | ||
tissue | 0.49 | ||
biological process | 0.41 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.94 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 50 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.94 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 50 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0