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  6. Sister chromatid cohesion protein PDS5 homolog A

Tbio Sister chromatid cohesion protein PDS5 homolog A

Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.

The protein encoded by this gene binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

 Comments

Property Summary

NCBI Gene PubMed Count 24
PubMed Score 51.09
PubTator Score 9.22

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (5)

Disease Target Count
IGA Glomerulonephritis 454
Disease Target Count P-value
atypical teratoid/rhabdoid tumor 1095 6.06070866502531E-7
sonic hedgehog group medulloblastoma 1482 1.87174359060857E-5
medulloblastoma, large-cell 6234 1.60608862776997E-4
psoriasis 6685 1.72724572233777E-4
glioblastoma 5572 0.0124204218988894
Waldenstrons macroglobulinemia 765 0.0155511046438395
spina bifida 1064 0.035817889435841
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0
Disease Target Count Z-score Confidence
Rheumatoid Arthritis 1171 0.0 2.0
Disease Target Count Z-score Confidence
Cornelia de Lange syndrome 21 4.312 2.2

Expression

  Differential Expression (8)

Disease log2 FC p
Rheumatoid Arthritis 1.500 0.019
Waldenstrons macroglobulinemia 1.038 0.016
psoriasis 1.800 0.000
sonic hedgehog group medulloblastoma 1.500 0.000
glioblastoma 1.100 0.012
atypical teratoid/rhabdoid tumor 1.400 0.000
medulloblastoma, large-cell 1.100 0.000
spina bifida -1.740 0.036

Synonym

Accession Q29RF7 Q2TTR5 Q68DF7 Q8N7J4 Q8NG14 Q9Y4D4
Symbols PIG54
SCC112
SCC-112

Gene

PDS5A

PANTHER Protein Class (3)

  Ortholog (15)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG
Pig OMA EggNOG
Opossum OMA Inparanoid
Platypus OMA Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA EggNOG Inparanoid
C. elegans OMA Inparanoid
S.cerevisiae OMA EggNOG Inparanoid

 GO Component (7)

 GO Process (5)

 Compartment GO Term (38)

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 MGI Term (14)

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 HCA RNA Cell Line (56)

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Pathway (13)

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 UniProt Keyword (10)

Gene RIF (7)

PMID Text
26051894 By interacting with a unique domain of Esco1, Pds5 recruits Esco1 to chromatin-bound cohesin complexes to form cohesion.
21865657 The data show a downregulation of proliferation-associated host gene PDS5A and suggest a role of PDS5A in HIV-1-induced cellular pathogenesis but not viral replication.
21069257 Data show that the siRNA-mediated knockdown of Pds5A affects sister chromatid cohesion but does not influence mitotic checkpoint function or the proliferation and survival of glioblastoma multiforme cells.
20359100 Observational study of gene-disease association. (HuGE Navigator)
19454010 Interaction of HIV-1 Tat with PDS5A in T-cells is identified by a proteomic strategy based on affinity chromatography coupled with mass spectrometry
17846787 SCC-112 improve cell proliferation and contributes to tumorigenesis by interacting with p63 and promoting cell cycling.
15019998 Findings suggest that the SCC-112 gene expression is likely to be associated with normal cell growth and proliferation.

AA Sequence 

MDFTAQPKPATALCGVVSADGKIAYPPGVKEITDKITTDEMIKRLKMVVKTFMDMDQDSEDEKQQYLPLA      1 - 70
LHLASEFFLRNPNKDVRLLVACCLADIFRIYAPEAPYTSHDKLKDIFLFITRQLKGLEDTKSPQFNRYFY     71 - 140
LLENLAWVKSYNICFELEDCNEIFIQLFRTLFSVINNSHNKKVQMHMLDLMSSIIMEGDGVTQELLDSIL    141 - 210
INLIPAHKNLNKQSFDLAKVLLKRTVQTIEACIANFFNQVLVLGRSSVSDLSEHVFDLIQELFAIDPHLL    211 - 280
LSVMPQLEFKLKSNDGEERLAVVRLLAKLFGSKDSDLATQNRPLWQCFLGRFNDIHVPVRLESVKFASHC    281 - 350
LMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVTIITAAKRDLALVNDQLLGFVRERTLDKRWRVRKEAMM    351 - 420
GLAQLYKKYCLHGEAGKEAAEKVSWIKDKLLHIYYQNSIDDKLLVEKIFAQYLVPHNLETEERMKCLYYL    421 - 490
YASLDPNAVKALNEMWKCQNMLRSHVRELLDLHKQPTSEANCSAMFGKLMTIAKNLPDPGKAQDFVKKFN    491 - 560
QVLGDDEKLRSQLELLISPTCSCKQADICVREIARKLANPKQPTNPFLEMVKFLLERIAPVHIDSEAISA    561 - 630
LVKLMNKSIEGTADDEEEGVSPDTAIRSGLELLKVLSFTHPTSFHSAETYESLLQCLRMEDDKVAEAAIQ    631 - 700
IFRNTGHKIETDLPQIRSTLIPILHQKAKRGTPHQAKQAVHCIHAIFTNKEVQLAQIFEPLSRSLNADVP    701 - 770
EQLITPLVSLGHISMLAPDQFASPMKSVVANFIVKDLLMNDRSTGEKNGKLWSPDEEVSPEVLAKVQAIK    771 - 840
LLVRWLLGMKNNQSKSANSTLRLLSAMLVSEGDLTEQKRISKSDMSRLRLAAGSAIMKLAQEPCYHEIIT    841 - 910
PEQFQLCALVINDECYQVRQIFAQKLHKALVKLLLPLEYMAIFALCAKDPVKERRAHARQCLLKNISIRR    911 - 980
EYIKQNPMATEKLLSLLPEYVVPYMIHLLAHDPDFTRSQDVDQLRDIKECLWFMLEVLMTKNENNSHAFM    981 - 1050
KKMAENIKLTRDAQSPDESKTNEKLYTVCDVALCVINSKSALCNADSPKDPVLPMKFFTQPEKDFCNDKS   1051 - 1120
YISEETRVLLLTGKPKPAGVLGAVNKPLSATGRKPYVRSTGTETGSNINVNSELNPSTGNRSREQSSEAA   1121 - 1190
ETGVSENEENPVRIISVTPVKNIDPVKNKEINSDQATQGNISSDRGKKRTVTAAGAENIQQKTDEKVDES   1191 - 1260
GPPAPSKPRRGRRPKSESQGNATKNDDLNKPINKGRKRAAVGQESPGGLEAGNAKAPKLQDLAKKAAPAE   1261 - 1330
RQIDLQR                                                                  1331 - 1337
//

Text Mined References (39)

PMID Year Title
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
26051894 2015 Esco1 Acetylates Cohesin via a Mechanism Different from That of Esco2.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24141881 2013 Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21865657 2012 HIV-1 infection suppresses expression of host cell cycle-associated gene PDS5A.
21697133 2011 Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21269460 2011 Initial characterization of the human central proteome.
21111234 2010 Sororin mediates sister chromatid cohesion by antagonizing Wapl.
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