Tbio MICB MHC class I polypeptide-related sequence B

Protein Summary

Description

Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• Q29980
• A2AC57
• A6NP85
• B0UZ10
• B2RAK2
• O14499
• O14500
• O19798
• O19799
• O19800
• O19801
• O19802
• O19803
• O78099
• O78100
• O78101
• O78102
• O78103
• O78104
• P79525
• P79541
• Q5GR31
• Q5GR37
• Q5GR41
• Q5GR42
• Q5GR43
• Q5GR44
• Q5GR46
• Q5GR48
• Q5RIY6
• Q5SSK1
• Q5ST25
• Q7JK51
• Q7YQ89
• Q861E6
• Q9MY18
• Q9MY19
• Q9MY20
• Q9UBH4
• Q9UBZ8
• Q9UEJ0
• MIC-B

Gene Name

• MICB

Ensembl ID

• ENST00000399150
• ENSP00000382103
• ENSG00000204516
• ENST00000427115
• ENSP00000395391
• ENST00000428416
• ENSP00000398412
• ENSG00000206449
• ENST00000436531
• ENSP00000409414
• ENSG00000238289
• ENST00000436655
• ENSP00000402484
• ENST00000438954
• ENSP00000398212
• ENSG00000234218
• ENST00000443156
• ENSP00000393355
• ENSG00000227772
• ENST00000546706
• ENSP00000449672
• ENSG00000231179
• ENST00000551608
• ENSP00000447696
• ENSG00000224378

Symbol

• PERB11.2
• PERB11.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
trait	0.97
protein domain	0.85
biological term	0.8
disease	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 397.58   (req: < 5)

Gene RIFs: 121   (req: <= 3)

Antibodies: 248   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 397.58   (req: >= 5)

Gene RIFs: 121   (req: > 3)

Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0