Tchem DDR2 Discoidin domain-containing receptor 2

Protein Summary

Description

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• Q16832
• Q7Z730
• Discoidin domain receptor 2

Gene Name

• DDR2

Ensembl ID

• ENST00000367921
• ENSP00000356898
• ENSG00000162733
• ENST00000367922
• ENSP00000356899
• ENST00000446985
• ENSP00000400309

Symbol

• NTRKR3
• TKT
• TYRO10
• TKT
• WRCN
• MIG20a
• NTRKR3
• TYRO10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
protein domain	0.99
virus perturbation	0.95
biological process	0.87
disease perturbation	0.83

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Ddr Family / Discoidin Domain-containing Receptor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 387.38   (req: < 5)

Gene RIFs: 101   (req: <= 3)

Antibodies: 400   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 387.38   (req: >= 5)

Gene RIFs: 101   (req: > 3)

Antibodies: 400   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 79

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5