Property Summary

NCBI Gene PubMed Count 15
PubMed Score 7.83
PubTator Score 12.60

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (21)

Disease log2 FC p
malignant mesothelioma -2.000 0.000
posterior fossa group B ependymoma 1.400 0.000
group 3 medulloblastoma 1.600 0.001
glioblastoma 1.100 0.000
juvenile dermatomyositis 1.093 0.000
Amyotrophic Lateral Sclerosis 1.085 0.000
Atopic dermatitis -1.200 0.000
non-small cell lung cancer -2.737 0.000
colon cancer -1.200 0.025
lung cancer -1.200 0.001
lung adenocarcinoma -1.900 0.000
pilocytic astrocytoma 1.200 0.000
psoriasis -1.500 0.000
lung carcinoma -1.400 0.000
breast carcinoma -1.300 0.000
spina bifida -1.149 0.036
Breast cancer -1.600 0.000
ductal carcinoma in situ -1.500 0.004
invasive ductal carcinoma -2.400 0.000
ulcerative colitis -1.200 0.000
ovarian cancer -2.700 0.000

Gene RIF (7)

PMID Text
25062045 Presented data suggest that the transient formation of dynamic PTPD1/EGFR signalling complexes strengthens EGF signalling by promoting the spatial propagation of EGFR phosphorylated species
21752600 The results that 2 non-synonymous markers in PTPN21 are associated with schizophrenia, further investigation of this locus is warranted.
20923765 PTPD1 is a novel component of the endocytic machinery that impacts on EGF receptor stability and on growth and motility of bladder cancer cells
19000305 In colorectal tumors, microsatellite repeats mutation rates are higher than the mean mutation frequency; the highest mutation frequency among 16 PTP genes
19000305 Observational study of gene-disease association. (HuGE Navigator)
18223254 PTPD1 is a component of a multivalent scaffold complex nucleated by FAK at specific intracellular sites
16918960 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence

MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYN      1 - 70
KQNQRRWVDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQA     71 - 140
IQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKVLEEATQKVALLHQKYRGLTAPDAEMLYMQE    141 - 210
VERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRWHDIANMSHNKSFFALELANKEETI    211 - 280
QFQTEDMETAKYIWRLCVARHKFYRLNQCNLQTQTVTVNPIRRRSSSRMSLPKPQPYVMPPPPQLHYNGH    281 - 350
YTEPYASSQDNLFVPNQNGYYCHSQTSLDRAQIDLNGRIRNGSVYSAHSTNSLNNPQPYLQPSPMSSNPS    351 - 420
ITGSDVMRPDYLPSHRHSAVIPPSYRPTPDYETVMKQLNRGLVHAERQSHSLRNLNIGSSYAYSRPAALV    421 - 490
YSQPEIREHAQLPSPAAAHCPFSLSYSFHSPSPYPYPAERRPVVGAVSVPELTNAQLQAQDYPSPNIMRT    491 - 560
QVYRPPPPYPPPRPANSTPDLSRHLYISSSNPDLITRRVHHSVQTFQEDSLPVAHSLQEVSEPLTAARHA    561 - 630
QLHKRNSIEVAGLSHGLEGLRLKERTLSASAAEVAPRAVSVGSQPSVFTERTQREGPEEAEGLRYGHKKS    631 - 700
LSDATMLIHSSEEEEDEDFEEESGARAPPARAREPRPGLAQDPPGCPRVLLAGPLHILEPKAHVPDAEKR    701 - 770
MMDSSPVRTTAEAQRPWRDGLLMPSMSESDLTTSGRYRARRDSLKKRPVSDLLSGKKNIVEGLPPLGGMK    771 - 840
KTRVDAKKIGPLKLAALNGLSLSRVPLPDEGKEVATRATNDERCKILEQRLEQGMVFTEYERILKKRLVD    841 - 910
GECSTARLPENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQD    911 - 980
FWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLL    981 - 1050
TGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVIL   1051 - 1120
SEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKSSRLI                   1121 - 1174
//

Text Mined References (19)

PMID Year Title
25062045 2014 Dynamic recruitment of protein tyrosine phosphatase PTPD1 to EGF stimulation sites potentiates EGFR activation.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21752600 2011 Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
20923765 2010 PTPD1 supports receptor stability and mitogenic signaling in bladder cancer cells.
19000305 2008 Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability.
18223254 2008 Protein-tyrosine phosphatase PTPD1 regulates focal adhesion kinase autophosphorylation and cell migration.
16918960 2006 Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
More...