Tchem PHKG1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

Protein Summary

Description

Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain and two calmodulin-binding domains. This protein is the catalytic member of a 16 subunit protein kinase complex which contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. This gene has two pseudogenes at chromosome 7q11.21 and one at chromosome 11p11.12. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• Q16816
• B7Z1D0
• F5H2S1
• Q75LP5
• PHK-gamma-M

Gene Name

• PHKG1

Ensembl ID

• ENST00000297373
• ENSP00000297373
• ENSG00000164776
• ENST00000452681
• ENSP00000445440

Symbol

• PHKG
• PHKG

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
protein domain	0.92
cell type or tissue	0.76
gene perturbation	0.75
PubMedID	0.64

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Phk Family / Phosphorylase B Kinase Gamma Catalytic Chain, Skeletal Muscle/heart Isoform

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.01   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 289   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.01   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1