Property Summary

NCBI Gene PubMed Count 68
PubMed Score 2966.40
PubTator Score 385.55

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
lung carcinoma 2844 5.33826131266551E-22
breast carcinoma 1614 3.80424466604587E-21
pilocytic astrocytoma 3086 2.14353033110223E-6
pituitary cancer 1972 5.10227441399564E-6
ovarian cancer 8492 1.10042671682053E-5
nasopharyngeal carcinoma 1056 1.44286371326637E-5
pancreatic cancer 2300 1.34491713769099E-4
ductal carcinoma in situ 1745 7.12271604113193E-4
psoriasis 6685 8.14441721233873E-4
invasive ductal carcinoma 2950 9.20533517001545E-4
cystic fibrosis 1670 0.00103263049247267
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00283426904912904
Multiple myeloma 1328 0.00303462910568915
group 4 medulloblastoma 1875 0.00324398507977656
osteosarcoma 7933 0.00625042602324793
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00632580923195849
colon cancer 1475 0.0224700353160371
spina bifida 1064 0.0430853957424171
Breast cancer 3099 0.0450046835994013

Expression

  Differential Expression (19)

Disease log2 FC p
Multiple myeloma 2.111 0.003
psoriasis -2.200 0.001
osteosarcoma -1.867 0.006
cystic fibrosis 1.290 0.001
intraductal papillary-mucinous carcinoma... 2.300 0.006
intraductal papillary-mucinous neoplasm ... 2.700 0.003
colon cancer -2.200 0.022
pancreatic cancer 1.600 0.000
Breast cancer 3.700 0.045
group 4 medulloblastoma -1.100 0.003
pilocytic astrocytoma -1.300 0.000
nasopharyngeal carcinoma -1.300 0.000
lung carcinoma 1.800 0.000
breast carcinoma 1.400 0.000
spina bifida -2.011 0.043
ductal carcinoma in situ 2.900 0.001
invasive ductal carcinoma 3.600 0.001
ovarian cancer 1.900 0.000
pituitary cancer 2.000 0.000

Synonym

Accession Q16778 A3KMC7 A8K110 Q4KMY1 Q5QNX0 Q9UE88
Symbols H2B
H2BQ
GL105
H2B.1
H2BFQ
H2BGL105

Gene

PDB

4NFT  

  Ortholog (1)

Species Source
Chimp OMA EggNOG

 GO Function (1)

Gene RIF (27)

PMID Text
27098497 CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent DNA repair resection.
26974126 The 2.7-A-resolution crystal structure of the human YL1-H2A.Z-H2B complex shows that YL1 binding, similarly to ANP32E binding, triggers an extension of the H2A.Z alphaC helix.
26904685 All cases with ARID1A expression are overlapped with H2B high expression. Among 15 cases with ARID1A and H2B coexpression, 13 are invasive ductal carcinoma and 2 are mucinous carcinoma. Our results indicate that ARID1A gene may be involved in carcinogenesis of some subtypes of breast cancer.
26852132 Gene expression analysis identified deregulation of histone H2A and H2B genes in all four cell lines ;histone pathways are associated with epirubicin resistance
26424599 Study provides the first observation of the proteolytic processing of histones H2B and H3 in human hepatocytes where four different clipping sites were localized in H3 and one in H2B.
26240340 analysis of a functional hotspot on ubiquitin that is required for the stimulation of human Dot1
25049226 Results show that the cotranscriptional ubiquitylation of histone H2B suggests that it may be more intimately involved in ongoing nucleosome turnover in the wake of Pol II.
24837678 H2B K34 ubiquitylation by the MOF-MSL complex is part of the protein networks involved in early steps of transcription elongation.
24339737 Knockdown of EZH2 increased the ubiquitination level of H2BK120.
22967069 Autoimmunity to isoAsp histone H2B suggests that this form of the autoantigen may be critical in the induction of anti-histone autoantibodies in human SLE.
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AA Sequence

MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDI      1 - 70
FERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK                   71 - 126
//

Text Mined References (71)

PMID Year Title
27098497 2016 CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection.
26974126 2016 Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1.
26904685 2016 Expressing Status and Correlation of ARID1A and Histone H2B on Breast Cancer.
26852132 2016 Downregulation of histone H2A and H2B pathways is associated with anthracycline sensitivity in breast cancer.
26424599 2015 Top-down and Middle-down Protein Analysis Reveals that Intact and Clipped Human Histones Differ in Post-translational Modification Patterns.
26240340 2015 Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin.
25049226 2014 Cotranscriptional histone H2B monoubiquitylation is tightly coupled with RNA polymerase II elongation rate.
24837678 2014 H2B ubiquitylation promotes RNA Pol II processivity via PAF1 and pTEFb.
24339737 2013 The oncogenic polycomb histone methyltransferase EZH2 methylates lysine 120 on histone H2B and competes ubiquitination.
23824326 2013 USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing.
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