| Tbio | Histone H2A type 2-C |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Aug 2015]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Aug 2015]
Comments
Property Summary
| NCBI Gene PubMed Count | 38 |
| Grant Count | 396 |
| R01 Count | 263 |
| Funding | $41,793,730.29 |
| PubMed Score | 1007.35 |
| PubTator Score | 2.50 |
| Disease | Z-score | Confidence |
|---|---|---|
| Lupus erythematosus 80 | 4.936 | 2.5 |
| Cancer 2,346 | 4.33 | 2.2 |
| Connective tissue disease 59 | 3.772 | 1.9 |
| Cleft palate 125 | 3.582 | 1.8 |
| Thyroiditis 25 | 3.064 | 1.5 |
| Leishmaniasis 49 | 3.006 | 1.5 |
| PMID | Text |
|---|---|
| 25065453 | Glycated-H2A histone is better bound by serum anti-DNA autoantibodies in systemic lupus erythematosus patients, and could be a likely trigger for the disease. |
| 22334663 | Our results provide mechanistic insight into how post-translational modification of H2A at the site of a photolesion initiates the repair process and directly affects the stability of the human genome. |
| 21633354 | Aurora-B-dependent phosphorylation of condensin promotes its association with histone H2A and H2A.Z, which we identify as conserved chromatin 'receptors' of condensin |
| 21596310 | L3MBTL2-specific RNAi resulted in increased expression of target genes that exhibited a significant reduction in H2A lysine 119 monoubiquitination. |
| 20838438 | AT1R modify the composition of histone H2A and post-translational modifications. |
| 20599239 | HIV-1 Tat activated transcription facilitates removal of histones H2A and H2B at the LTR, and the FACT complex, at least consisting of SPT16 and SSRP1, may be responsible for their removal |
| 19667409 | Results demonstrate the potential of C-terminal truncated H2A to contribute to the process of carcinogenesis through epigenetic mechanisms. |
| 19500350 | Study demonstrated that RNF168 is endowed with ubiquitin ligase activity both in vitro and in vivo, which targets histones H2A and H2AX, but not H2B, forming K63 polyubiquitin chains. |
| 19385636 | The change in nucleosome core particle conformation induced by global histone acetylation is dependent on H2A/H2A.Z acetylation. |
| 18593899 | DDB1-CUL4B(DDB2) is more efficient than DDB1-CUL4A(DDB2) in monoubiquitinating histone H2A in vitro. |
| More... |
| PMID | Year | Title |
|---|---|---|
| 25470042 | 2014 | TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein. |
| 25362550 | 2015 | A comprehensive view of the epigenetic landscape part I: DNA methylation, passive and active DNA demethylation pathways and histone variants. |
| 25065453 | 2015 | Glycated-H2A histone is better bound by serum anti-DNA autoantibodies in SLE patients: glycated-histones as likely trigger for SLE? |
| 24352239 | 2014 | Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification. |
| 24140421 | 2013 | VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription. |
| 23533145 | 2013 | In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. |
| 22980979 | 2012 | RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling. |
| 22713238 | 2012 | A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase. |
| 22334663 | 2012 | Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase. |
| 21925322 | 2011 | Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. |
| More... |
