Tbio NRF1 Nuclear respiratory factor 1

Protein Summary

Description

Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]

Uniprot Accession IDs

• Q16656
• A8K4C6
• B4DDV6
• Q15305
• Q96AN2
• NRF-1

Gene Name

• NRF1

Ensembl ID

• ENST00000223190
• ENSP00000223190
• ENSG00000106459
• ENST00000311967
• ENSP00000309826
• ENST00000353868
• ENSP00000342351
• ENST00000393230
• ENSP00000376922
• ENST00000393232
• ENSP00000376924

Symbol

• ALPHA-PAL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
transcription factor binding site profile	0.95
disease perturbation	0.87
histone modification site profile	0.86
transcription factor	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.91   (req: < 5)

Gene RIFs: 81   (req: <= 3)

Antibodies: 409   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.91   (req: >= 5)

Gene RIFs: 81   (req: > 3)

Antibodies: 409   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0