Tbio NFIL3 Nuclear factor interleukin-3-regulated protein

Protein Summary

Description

Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity). The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]

Uniprot Accession IDs

• Q16649
• B2R9Y8
• Q14211
• Q6FGQ8
• Q96HS0

Gene Name

• NFIL3

Ensembl ID

• ENST00000297689
• ENSP00000297689
• ENSG00000165030

Symbol

• E4BP4
• IL3BP1
• E4BP4
• IL3BP1
• NFIL3A
• NF-IL3A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
gene perturbation	0.99
disease perturbation	0.96
PubMedID	0.91
transcription factor binding site profile	0.91

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Nuclear Factor Interleukin-3-regulated Protein

DTO Classes

Protein / Transcription Factor / Nuclear Factor Interleukin-3-regulated Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.33   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 345   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.33   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 345   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0