Tbio POU2AF1 POU domain class 2-associating factor 1

Protein Summary

Description

Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.

Uniprot Accession IDs

• Q16633
• B2R8Z9
• Q14983

Gene Name

• POU2AF1

Ensembl ID

• ENST00000393067
• ENSP00000376786
• ENSG00000110777

Symbol

• OBF1
• BOB1
• OBF1
• OCAB
• OBF-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.68
kinase perturbation	0.6
phenotype	0.55
tissue	0.55
PubMedID	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.09   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 502   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.09   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 502   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0