Tclin NTRK2 BDNF/NT-3 growth factors receptor

Protein Summary

Description

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Uniprot Accession IDs

• Q16620
• B1ANZ4
• B4DFV9
• Q16675
• Q59GJ1
• Q8WXJ5
• Q8WXJ6
• Q8WXJ7

Gene Name

• NTRK2

Ensembl ID

• ENST00000277120
• ENSP00000277120
• ENSG00000148053
• ENST00000304053
• ENSP00000306167
• ENST00000323115
• ENSP00000314586
• ENST00000359847
• ENSP00000352906
• ENST00000376208
• ENSP00000365381
• ENST00000376213
• ENSP00000365386
• ENST00000376214
• ENSP00000365387
• ENST00000395882
• ENSP00000379221

Symbol

• TRKB
• OBHD
• TRKB
• trk-B
• EIEE58
• GP145-TrkB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	1
protein domain	1
biological term	0.97
PubMedID	0.96

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Trk Family / Bdnf/nt-3 Growth Factors Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1788.28   (req: < 5)

Gene RIFs: 300   (req: <= 3)

Antibodies: 1219   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1788.28   (req: >= 5)

Gene RIFs: 300   (req: > 3)

Antibodies: 1219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 184

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6