| Tbio | Cardiotrophin-1 |
Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.
The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Comments
| Disease | Target Count |
|---|---|
| Cardiomegaly | 66 |
| Hypercholesterolemia | 27 |
| Hypotension | 53 |
| Insulin Resistance | 50 |
| Kidney Diseases | 86 |
| Necrosis | 51 |
| Obesity | 616 |
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7933 | 6.23516680742176E-5 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Heart disease | 279 | 3.81 | 1.9 |
| Myocardial Infarction | 126 | 3.233 | 1.6 |
| Hypertension | 293 | 3.045 | 1.5 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Opossum | OMA EggNOG Inparanoid |
| Platypus | OMA EggNOG |
| PMID | Text |
|---|---|
| 26621340 | non-diabetic subjects who were overweight or obesity had significantly lower cardiotrophin-1 concentrations than those with normal weight, and both obesity and being overweight were inversely associated with cardiotrophin-1 levels. |
| 26188636 | This paper will review many aspects of CT-1 physiological role in several organs and discuss data for consideration in therapeutic approaches. |
| 25919795 | biliary epithelium-derived CT-1 may exert a profibrogenic potential in PCLD. |
| 25689900 | Data show that cardiotrophin-1 is positively related to brachial-ankle pulse-wave velocity (baPWV) independent of traditional cardiometabolic risk factors for arterial stiffness. |
| 25025664 | this study, even though preliminary and awaiting further confirmation by independent replication, provides first evidence that common genetic variation in CTF1 could contribute to insulin sensitivity in humans. |
| 24401751 | Study correlates CT-1 levels with ambulatory and central BP, as well as with pulse wave velocity in patients with essential hypertension. |
| 24366078 | exaggerated cardiomyocyte production of cardiotrophin-1 in response to increased left ventricular end-diastolic stress may contribute to fibrosis through stimulation of fibroblasts in heart failure of hypertensive origin. |
| 24344663 | CT-1 is differentially induced in the myocardium of infants with congenital cardiac defects depending on hypoxemia, and may mediate myocardial hypertrophy and dysfunction. |
| 24054317 | Subjects with impaired glucose tolerance (IGT) and newly diagnosed diabetes (NDD) have significantly higher CT-1 concentrations than those with normal glucose tolerance. IGT and NDD are positively associated with CT-1 concentrations. |
| 23935888 | CT-1 induces the proteolytic potential in human aortic endothelial cells by upregulating MMP-1 expression. |
| More... |
| PMID | Year | Title |
|---|---|---|
| 26621340 | 2015 | Cardiotrophin-1 is inversely associated with obesity in non-diabetic individuals. |
| 26188636 | 2015 | Cardiotrophin-1: A multifaceted cytokine. |
| 25919795 | 2015 | A Potential Profibrogenic Role of Biliary Epithelium-Derived Cardiotrophin-1 in Pediatric Cholestatic Liver Disease. |
| 25689900 | 2015 | Cardiotrophin-1 is associated with increased risk of arterial stiffness. |
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 25025664 | 2014 | Common genetic variation in the human CTF1 locus, encoding cardiotrophin-1, determines insulin sensitivity. |
| 24401751 | 2014 | Association between cardiotrophin 1 levels and central blood pressure in untreated patients with essential hypertension. |
| 24366078 | 2014 | Association of cardiotrophin-1 with myocardial fibrosis in hypertensive patients with heart failure. |
| 24344663 | 2014 | Myocardial cardiotrophin-1 is differentially induced in congenital cardiac defects depending on hypoxemia. |
| 24097068 | 2013 | Discovery and refinement of loci associated with lipid levels. |
| More... |
