Tdark LPAL2 Putative apolipoprotein(a)-like protein 2

Protein Summary

Description

Apolipoprotein(a) is the distinguishing protein moiety of lipoprotein(a), of which elevated plasma levels are correlated with an increased risk of atherosclerosis. This gene is similar to the lipoprotein, Lp(a) gene, but all transcripts produced by this gene contain a truncated open reading frame and are candidates for nonsense-mediated decay. Consequently, this gene is considered to be a pseudogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

Uniprot Accession IDs

• Q16609
• E1P5B4
• Apo(a)-like protein 2

Gene Name

• LPAL2

Symbol

• APOARGC
• APOA2
• APOAL
• APOARGC
• apo(a)rg-C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.7
trait	0.61
cell type or tissue	0.51
disease	0.48
phenotype	0.47

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Putative Apolipoprotein(a)-like Protein 2

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Putative Apolipoprotein(a)-like Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0