Property Summary

NCBI Gene PubMed Count 82
PubMed Score 170.17
PubTator Score 119.06

Knowledge Summary

Patent (9,007)


  Disease Sources (4)

Disease Target Count
Dermatitis, Allergic Contact 66
Disease Target Count P-value
non-small cell lung carcinoma 413 3.08969528681912E-30
lung adenocarcinoma 2714 1.8492245760266E-13
ovarian cancer 8492 4.68546250203754E-9
lung carcinoma 2844 1.29225801145025E-8
pilocytic astrocytoma 3086 3.63191820653019E-7
lung cancer 4473 8.13061154031973E-7
tuberculosis 1563 3.38940065695406E-6
posterior fossa group A ependymoma 1511 7.06241665636196E-6
pediatric high grade glioma 2712 1.96741762080592E-5
atypical teratoid / rhabdoid tumor 4369 2.48776287098886E-5
interstitial cystitis 2299 5.38018495784744E-5
medulloblastoma, large-cell 6234 5.9972931226431E-5
glioblastoma 5572 1.04210358032383E-4
astrocytic glioma 2241 3.94079453815848E-4
medulloblastoma 1524 0.00121345583390088
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00205205331221128
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00254288645094465
oligodendroglioma 2849 0.00287459244909146
primitive neuroectodermal tumor 3031 0.0029717694030292
ulcerative colitis 2087 0.0035436342615633
osteosarcoma 7933 0.00430702561859163
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0185643561894269
psoriasis 6685 0.0337699280440677
Disease Target Count Z-score Confidence
Cardiovascular system disease 194 0.0 1.0
Disease Target Count Z-score Confidence
Migraine 79 4.87 2.4
Hypertension 293 3.66 1.8
Primary angle-closure glaucoma 11 3.451 1.7



Accession Q16602 A8K6G5 A8KAD3 Q53S02 Q53TS5 CGRP type 1 receptor
Symbols CRLR



4RWF   3AQF   3N7P   3N7R   3N7S   4RWG  

  Ortholog (13)

  TechDev Info (1)

Gene RIF (56)

25982113 Data suggest that ligand binding of a G protein-coupled receptor (GPCR) may inform drug development targeting calcitonin receptor-like receptor (CLR):receptor activity-modifying proteins RAMP1/2 complexes.
25591908 STC1 interferes with CALCRL signaling during osteoblastogenesis via adenylate cyclase inhibition.
24831942 the AM system is widely expressed in human thymus from newborns; both AM1 receptor components CLR and RAMP2, but not RAMP3, are not associated with the plasma membrane of TECs and thymocytes but are located intracellularly, notably in the nucleus
24199627 Data suggest isoforms of RAMP (receptor activity-modifying protein) modulate accessibility of peptides to residues situated on CALCRL N-terminal domain; RAMP3/RAMP2/RAMP1 appear to alter accessibility of specific residues at CALCRL-RAMP interface.
24169318 CRLR expression is upregulated in the fetal lung with increasing gestational age.
24047872 An alanine scan of residues 271-294 of CLR showed that the ability of CGRP to produce cAMP was impaired by point mutations at 13 residues; most of these also impaired the response to adrenomedullin (AM).
23969937 The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis.
23797962 Two CALCRL variants were associated with risk for gestational diabetes.
22933837 The study implicates genetic variation at the CALCRL gene in the pathogenesis of primary angle closure glaucoma in an Australian Caucasian cohort.
22484227 CLR and RAMP1 co-localize in the enteric nervous system of the stomach, ileum and colon, and are in close proximity to their ligands CGRP and IMD

AA Sequence

YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN                                 421 - 461

Text Mined References (85)

PMID Year Title
25982113 2015 Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.
25591908 2015 STC1 interference on calcitonin family of receptors signaling during osteoblastogenesis via adenylate cyclase inhibition.
24831942 2014 Expression and distribution of the adrenomedullin system in newborn human thymus.
24199627 2014 Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology.
24169318 2014 Adrenomedullin expression in the developing human fetal lung.
24047872 2013 The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach.
23969937 2013 The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis.
23797962 2014 Adrenomedullin signaling pathway polymorphisms and adverse pregnancy outcomes.
23597562 2013 Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties.
22933837 2012 A cross-ethnicity investigation of genes previously implicated in primary angle closure glaucoma.