Tclin CALCRL Calcitonin gene-related peptide type 1 receptor

Protein Summary

Description

Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Uniprot Accession IDs

• Q16602
• A8K6G5
• A8KAD3
• Q53S02
• Q53TS5
• CGRP type 1 receptor

Gene Name

• CALCRL

Ensembl ID

• ENST00000392370
• ENSP00000376177
• ENSG00000064989
• ENST00000409998
• ENSP00000386972
• ENST00000410068
• ENSP00000387190

Symbol

• CGRPR
• CRLR
• CGRPR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.94
protein domain	0.85
cellular component	0.78
gene perturbation	0.74
biological term	0.65

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class B Secretin Like / Calcitonin Receptor / Calcitonin Gene-related Peptide Type 1 Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.79   (req: < 5)

Gene RIFs: 66   (req: <= 3)

Antibodies: 220   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.79   (req: >= 5)

Gene RIFs: 66   (req: > 3)

Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 483

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4