Property Summary

NCBI Gene PubMed Count 16
PubMed Score 8.77
PubTator Score 6.51

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
malignant mesothelioma 3163 2.82838949836979E-8
lung cancer 4473 5.77986648889315E-6
invasive ductal carcinoma 2950 0.0073658874681632
colon cancer 1475 0.0458989446504682
Disease Target Count Z-score Confidence
Rabies 19 3.682 1.8

Expression

  Differential Expression (4)

Disease log2 FC p
malignant mesothelioma 4.600 0.000
lung cancer 4.400 0.000
colon cancer 1.900 0.046
invasive ductal carcinoma 1.300 0.007

Synonym

Accession Q16600 Q5T1G9 Q8TAS5
Symbols MOK2
HOK-2

Gene

  Ortholog (4)

Species Source
Chimp OMA EggNOG
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG

Pathway (1)

Gene RIF (7)

PMID Text
20641033 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
19490114 Data identified Ser38 and Ser129 of hsMOK2 as phosphorylation sites of JNK3 kinase, and Ser46 as a phosphorylation site of Aurora A and protein kinase A.
17760566 Results indicate that pathogenic mutations in lamin A/C lead to sequestration of hsMOK2 into nuclear aggregates, which may deregulate MOK2 target genes.
16385451 Observational study of gene-disease association. (HuGE Navigator)
12409453 In this study, we identify a novel interaction between lamin A/C and hsMOK2 by using the yeast two-hybrid system

AA Sequence

MASTITGSQDCIVNHRGEVDGEPELDISPCQQWGEASSPISRNRDSVMTLQSGCFENIESETYLPLKVSS      1 - 70
QIDTQDSSVKFCKNEPQDHQESRRLFVMEESTERKVIKGESCSENLQVKLVSDGQELASPLLNGEATCQN     71 - 140
GQLKESLDPIDCNCKDIHGWKSQVVSCSQQRAHTEEKPCDHNNCGKILNTSPDGHPYEKIHTAEKQYECS    141 - 210
QCGKNFSQSSELLLHQRDHTEEKPYKCEQCGKGFTRSSSLLIHQAVHTDEKPYKCDKCGKGFTRSSSLLI    211 - 280
HHAVHTGEKPYKCDKCGKGFSQSSKLHIHQRVHTGEKPYECEECGMSFSQRSNLHIHQRVHTGERPYKCG    281 - 350
ECGKGFSQSSNLHIHRCIHTGEKPYQCYECGKGFSQSSDLRIHLRVHTGEKPYHCGKCGKGFSQSSKLLI    351 - 420
HQRVHTGEKPYECSKCGKGFSQSSNLHIHQRVHKKDPR                                    421 - 458
//

Text Mined References (17)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
20641033 2011 Polymorphisms in predicted miRNA binding sites and osteoporosis.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
19490114 2009 Phosphorylation-dependent binding of human transcription factor MOK2 to lamin A/C.
17760566 2008 Mislocalization of human transcription factor MOK2 in the presence of pathogenic mutations of lamin A/C.
17081983 2006 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
16385451 2006 A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
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