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Tbio
TAF9
Transcription initiation factor TFIID subunit 9

Protein Summary
Description
Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217893
  • ENSP00000217893
  • ENSG00000273841
  • ENST00000328663
  • ENSP00000370193
  • ENST00000506736
  • ENSP00000421873
  • ENST00000615404
  • ENSP00000478935
  • ENSG00000276463
  • ENST00000616867
  • ENSP00000477750
  • ENST00000617893
  • ENSP00000477611

Symbol
  • TAF2G
  • TAFII31
  • TAF2G
  • TAFII31
  • TAFII32
  • MGC:5067
  • TAFII-31
  • TAFII-32
  • TAFIID32
  • STAF31/32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
hub protein
0.98
biological process
0.97
disease perturbation
0.95
molecular function
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.02   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.02   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0