Tchem MAP3K11 Mitogen-activated protein kinase kinase kinase 11

Protein Summary

Description

Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q16584
• B4DS76
• Q53H00
• Q59F06
• Q6P2G4

Gene Name

• MAP3K11

Ensembl ID

• ENST00000309100
• ENSP00000309597
• ENSG00000173327
• ENST00000530153
• ENSP00000433886

Symbol

• MLK3
• PTK1
• SPRK
• MLK3
• PTK1
• SPRK
• MLK-3
• MEKK11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
disease perturbation	0.97
protein domain	0.97
hub protein	0.92
transcription factor binding site profile	0.87

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tkl Group / Mlk Family / Mlk Subfamily / Mitogen-activated Protein Kinase Kinase Kinase 11

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.91   (req: < 5)

Gene RIFs: 68   (req: <= 3)

Antibodies: 276   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.91   (req: >= 5)

Gene RIFs: 68   (req: > 3)

Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 22

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2