| Tbio | Dihydropyrimidinase-related protein 2 |
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Alzheimer Disease | 83 | 0.0 | 0.0 |
| Osteoarthritis | 184 | 0.0 | 0.0 |
| Schizophrenia, Paranoid | 1 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| breast carcinoma | 1637 | 1.4e-37 |
| non-small cell lung cancer | 2890 | 1.1e-23 |
| Breast cancer | 3577 | 2.7e-13 |
| lung adenocarcinoma | 2716 | 2.1e-11 |
| tuberculosis | 2010 | 8.6e-10 |
| ovarian cancer | 8519 | 7.9e-08 |
| Duchenne muscular dystrophy | 601 | 1.9e-07 |
| lung cancer | 4740 | 2.3e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.2e-04 |
| invasive ductal carcinoma | 2950 | 4.7e-04 |
| ulcerative colitis | 1819 | 6.8e-04 |
| pancreatic cancer | 2398 | 9.8e-04 |
| ductal carcinoma in situ | 1744 | 1.6e-03 |
| primary pancreatic ductal adenocarcinoma | 1108 | 1.7e-03 |
| acute myeloid leukemia | 783 | 1.8e-03 |
| medulloblastoma, large-cell | 6241 | 2.3e-03 |
| limb girdle muscular dystrophy 2I | 32 | 3.6e-03 |
| Becker muscular dystrophy | 191 | 6.8e-03 |
| autosomal dominant Emery-Dreifuss muscular dystrophy | 510 | 7.4e-03 |
| subependymal giant cell astrocytoma | 2287 | 8.3e-03 |
| gastric carcinoma | 807 | 1.4e-02 |
| dermatomyositis | 966 | 1.5e-02 |
| Waldenstrons macroglobulinemia | 765 | 3.3e-02 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | -2.600 | 1.8e-03 |
| atypical teratoid / rhabdoid tumor | -1.900 | 2.2e-04 |
| autosomal dominant Emery-Dreifuss muscul... | 1.402 | 7.4e-03 |
| Becker muscular dystrophy | 1.204 | 6.8e-03 |
| Breast cancer | -2.300 | 2.7e-13 |
| breast carcinoma | -1.600 | 1.4e-37 |
| dermatomyositis | 1.100 | 1.5e-02 |
| Duchenne muscular dystrophy | 1.589 | 1.9e-07 |
| ductal carcinoma in situ | -1.100 | 1.6e-03 |
| gastric carcinoma | 1.200 | 1.4e-02 |
| invasive ductal carcinoma | -1.900 | 4.7e-04 |
| limb girdle muscular dystrophy 2I | 1.054 | 3.6e-03 |
| lung adenocarcinoma | -1.100 | 2.1e-11 |
| lung cancer | -2.200 | 2.3e-05 |
| medulloblastoma, large-cell | -1.600 | 2.3e-03 |
| non-small cell lung cancer | -1.955 | 1.1e-23 |
| ovarian cancer | -3.700 | 7.9e-08 |
| pancreatic cancer | 1.500 | 9.8e-04 |
| primary pancreatic ductal adenocarcinoma | 1.487 | 1.7e-03 |
| subependymal giant cell astrocytoma | -1.248 | 8.3e-03 |
| tuberculosis | 2.500 | 8.6e-10 |
| ulcerative colitis | 1.100 | 6.8e-04 |
| Waldenstrons macroglobulinemia | 1.548 | 3.3e-02 |
MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGI 1 - 70 DVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSLHVD 71 - 140 ISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQ 141 - 210 RILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPIT 211 - 280 ASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTL 281 - 350 IPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTI 351 - 420 SAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAE 421 - 490 LRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPPVRNLHQSGFSLSGAQIDDNIPRRTTQRIVA 491 - 560 PPGGRANITSLG 561 - 572 //
