Tbio GPR162 Probable G-protein coupled receptor 162

Protein Summary

Description

Orphan receptor. This gene was identified upon genomic analysis of a gene-dense region at human chromosome 12p13. It appears to be mainly expressed in the brain; however, its function is not known. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q16538
• Q16664
• Q59EH5
• Q66K56

Gene Name

• GPR162

Ensembl ID

• ENST00000311268
• ENSP00000311528
• ENSG00000250510
• ENST00000428545
• ENSP00000399670

Symbol

• GRCA
• A-2
• GRCA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.9
cellular component	0.67
kinase perturbation	0.66
histone modification site profile	0.65
cell type or tissue	0.61

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Melanin-concentrating Hormone Receptor / Probable G-protein Coupled Receptor 162

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.75   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 106   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.75   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0