Tclin NTRK3 NT-3 growth factor receptor

Protein Summary

Description

Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Uniprot Accession IDs

• Q16288
• B7Z4C5
• E9PG56
• H0YND1
• O75682
• Q12827
• Q16289

Gene Name

• NTRK3

Ensembl ID

• ENST00000317501
• ENSP00000318328
• ENSG00000140538
• ENST00000355254
• ENSP00000347397
• ENST00000357724
• ENSP00000350356
• ENST00000360948
• ENSP00000354207
• ENST00000394480
• ENSP00000377990
• ENST00000540489
• ENSP00000444673
• ENST00000557856
• ENSP00000453959
• ENST00000629765
• ENSP00000485864

Symbol

• TRKC
• TRKC
• GP145-TrkC
• gp145(trkC)

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
protein domain	1
molecular function	0.99
microRNA	0.86
PubMedID	0.8

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Trk Family / Nt-3 Growth Factor Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 590.64   (req: < 5)

Gene RIFs: 131   (req: <= 3)

Antibodies: 696   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 590.64   (req: >= 5)

Gene RIFs: 131   (req: > 3)

Antibodies: 696   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 143

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4