Property Summary

NCBI Gene PubMed Count 11
Grant Count 38
R01 Count 24
Funding $3,649,398.16
PubMed Score 59.25
PubTator Score 24.93

Knowledge Summary

Patent (1,725)

Gene RIF (2)

PMID Text
25156905 Identification of a novel X-linked stop mutation in CNGA2 (c.634C>T, p.R212*) in two brothers with isolated congenital anosmia.
16533895 The results showed that it is predominantly the charge of the E342 residue in the P-loop, rather than the pore helix dipoles, which controls the cation-anion selectivity of the CNGA2 channel.

AA Sequence

MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQQGRSGFRRIV      1 - 70
RLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGEDKGTKKKFELFVLDPAGDWY     71 - 140
YCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRLRTGFLEQGLLVKDTKK    141 - 210
LRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVL    211 - 280
YILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEY    281 - 350
LFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNK    351 - 420
KTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKE    421 - 490
MYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAV    491 - 560
TEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEKLGQLETNMETLYTRFGRLLAEYTGAQQKLK    561 - 630
QRITVLETKMKQNNEDDYLSDGMNSPELAAADEP                                        631 - 664
//

Text Mined References (12)

PMID Year Title
25156905 2015 The first mutation in CNGA2 in two brothers with anosmia.
16959974 2006 The consensus coding sequences of human breast and colorectal cancers.
16533895 2006 A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channel.
16382102 2005 International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14618336 2003 Expression of olfactory-type cyclic nucleotide-gated channel (CNGA2) in vascular tissues.
14604981 2004 Assembly and trafficking of a multiprotein ROMK (Kir 1.1) channel complex by PDZ interactions.
12626507 2003 Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
9539801 1998 An isoform of the rod photoreceptor cyclic nucleotide-gated channel beta subunit expressed in olfactory neurons.
More...