Property Summary

NCBI Gene PubMed Count 32
Grant Count 11
R01 Count 5
Funding $1,554,651.82
PubMed Score 60.32
PubTator Score 14.21

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (5)

Disease log2 FC p
psoriasis -4.600 0.000
osteosarcoma -1.550 0.003
atypical teratoid / rhabdoid tumor 1.100 0.009
glioblastoma 1.100 0.002
group 4 medulloblastoma 1.600 0.002

Gene RIF (13)

PMID Text
26635365 Rab11A and Rab11B differentially regulate intracellular trafficking of PAR1 through distinct endosomal sorting mechanisms
25070890 we determined a crystal structure of the PKG II LZ-Rab11b complex. The PKG II LZ domain presents a mostly nonpolar surface onto which Rab11b docks, through van der Waals interactions
24589086 Upon Rab11b depletion, FGFR4 is trapped in the pericentriolar recycling compartment.
24141907 the predominant mechanism of melanin transfer is keratinocyte-induced exocytosis, mediated by Rab11b through remodeling of the melanosome membrane, followed by subsequent endocytosis by keratinocytes
22561749 Data show that the cAMP/PKA/CREB signaling pathway initiates acidosis-induced V-ATPase trafficking in salivary ducts via regulation of Rab11b expression.
21248079 These findings reveal a novel role for Rab11b in limiting, rather than promoting, the plasma membrane expression of Cav1.2 L-type Ca2+ channels.
20877624 Observational study of gene-disease association. (HuGE Navigator)
20717956 These data introduce Rab11b as a crucial regulator and Rip11 as mediator of acidosis-induced V-ATPase traffic in duct cells of submandibular gland.
20686666 propose a model where Rab11B specifically transports vesicles derived from the Golgi to the immature Inner Membrane Complex of the growing daughter parasites.
20622010 RAB11(Q67L) mutant induces significant reversal of HLA-I A2 downregulation by HIV-1 Nef through redistributing HLA-I A2 from the perinuclear vesicles to the peripheral punctate vesicles at the plasma membrane
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AA Sequence

MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQ      1 - 70
ERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEAR     71 - 140
AFAEKNNLSFIETSALDSTNVEEAFKNILTEIYRIVSQKQIADRAAHDESPGNNVVDISVPPTTDGQKPN    141 - 210
KLQCCQNL                                                                  211 - 218
//

Text Mined References (39)

PMID Year Title
26635365 2016 Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25556234 2015 New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein.
25468996 2014 E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
25070890 2014 Crystal structure of the cGMP-dependent protein kinase II leucine zipper and Rab11b protein complex reveals molecular details of G-kinase-specific interactions.
24589086 2014 Photoactivation approaches reveal a role for Rab11 in FGFR4 recycling and signalling.
24141907 2014 Rab11b mediates melanin transfer between donor melanocytes and acceptor keratinocytes via coupled exo/endocytosis.
24023390 2013 Large-scale top-down proteomics of the human proteome: membrane proteins, mitochondria, and senescence.
24006491 2013 Identification and characterization of multiple novel Rab-myosin Va interactions.
23572552 2013 ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.
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