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Tdark Clusterin-like protein 1


 Comments

Property Summary

NCBI Gene PubMed Count 8
PubMed Score 2.40
PubTator Score 2.17

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count
Mammary Neoplasms 410
Disease Target Count P-value
lung carcinoma 2844 5.88842344031389E-23
psoriasis 6685 1.24531795071791E-18
sonic hedgehog group medulloblastoma 1482 1.06632497379358E-7
pediatric high grade glioma 2712 5.32454415841033E-4
pituitary cancer 1972 0.00162017616820987
glioblastoma 5572 0.00477142866339816
Disease Target Count Z-score Confidence
Myopia 99 3.416 1.7

Expression

  Differential Expression (6)

Disease log2 FC p
glioblastoma -1.300 0.005
sonic hedgehog group medulloblastoma -1.700 0.000
pediatric high grade glioma -1.200 0.001
lung carcinoma 1.400 0.000
pituitary cancer 1.100 0.002
psoriasis -1.400 0.000

Synonym

Accession Q15846 A0FDN7
Symbols RA337M

Gene

CLUL1

  Ortholog (11)

Species Source
Chimp OMA EggNOG
Macaque OMA Inparanoid
Rat OMA Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Zebrafish OMA EggNOG Inparanoid

 GO Component (1)

 GO Process (1)

 Compartment GO Term (5)

 GWAS Trait (1)

 HCA RNA Cell Line (56)

See all...

 UniProt Keyword (7)

Gene RIF (3)

PMID Text
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence 

MKPPLLVFIVCLLWLKDSHCAPTWKDKTAISENLKSFSEVGEIDADEEVKKALTGIKQMKIMMERKEKEH      1 - 70
TNLMSTLKKCREEKQEALKLLNEVQEHLEEEERLCRESLADSWGECRSCLENNCMRIYTTCQPSWSSVKN     71 - 140
KIERFFRKIYQFLFPFHEDNEKDLPISEKLIEEDAQLTQMEDVFSQLTVDVNSLFNRSFNVFRQMQQEFD    141 - 210
QTFQSHFISDTDLTEPYFFPAFSKEPMTKADLEQCWDIPNFFQLFCNFSVSIYESVSETITKMLKAIEDL    211 - 280
PKQDKAPDHGGLISKMLPGQDRGLCGELDQNLSRCFKFHEKCQKCQAHLSEDCPDVPALHTELDEAIRLV    281 - 350
NVSNQQYGQILQMTRKHLEDTAYLVEKMRGQFGWVSELANQAPETEIIFNSIQVVPRIHEGNISKQDETM    351 - 420
MTDLSILPSSNFTLKIPLEESAESSNFIGYVVAKALQHFKEHFKTW                            421 - 466
//

Text Mined References (8)

PMID Year Title
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
17286855 2007 Mapping of transcription start sites of human retina expressed genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14507903 2003 Comparative analysis and expression of CLUL1, a cone photoreceptor-specific gene.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
10675623 2000 Molecular cloning, characterization and expression of a novel retinal clusterin-like protein cDNA.