| Tchem | Serine/threonine-protein kinase STK11 |
Isoform 2: Has a role in spermiogenesis.
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| Ligand Count | 2 |
| NCBI Gene PubMed Count | 367 |
| PubMed Score | 998.28 |
| PubTator Score | 708.57 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Peutz-Jeghers syndrome | 21 | 7.9 | 3.9 |
| Adenocarcinoma | 122 | 0.0 | 0.0 |
| Adenocarcinoma of lung | 142 | 0.0 | 0.0 |
| Carcinoma, Pancreatic Ductal | 20 | 0.0 | 0.0 |
| Carcinoma, Squamous Cell | 110 | 0.0 | 0.0 |
| Hypertension | 396 | 0.0 | 0.0 |
| Hypertrophy, Left Ventricular | 24 | 0.0 | 0.0 |
| Intestinal Polyposis | 6 | 0.0 | 0.0 |
| Lung Neoplasms | 232 | 0.0 | 0.0 |
| Pancreatic Neoplasms | 85 | 0.0 | 0.0 |
| Testicular Germ Cell Tumor | 14 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Hamman-Rich syndrome | 34 |
| non-small cell lung cancer | 2890 |
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 2.2e-09 |
| psoriasis | 6694 | 1.0e-04 |
| diabetes mellitus | 1728 | 1.5e-03 |
| non primary Sjogren syndrome sicca | 891 | 1.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Alzheimer's disease | 658 | 0.0 | 0.8 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Breast cancer | 3578 | 0.0 | 5.0 |
| lung cancer | 4740 | 0.0 | 1.5 |
| ovarian cancer | 8520 | 0.0 | 7.87054005141921E-4 |
| Disease | Target Count |
|---|---|
| CMM1 | 5 |
| Carcinoma of pancreas | 5 |
| Intestinal polyposis syndrome | 1 |
| Squamous cell carcinoma | 129 |
| Disease | log2 FC | p |
|---|---|---|
| ovarian cancer | 1.100 | 7.9e-04 |
| diabetes mellitus | -1.200 | 1.5e-03 |
| non primary Sjogren syndrome sicca | 1.100 | 1.4e-02 |
| osteosarcoma | -3.699 | 2.2e-09 |
| psoriasis | 1.300 | 1.0e-04 |
MEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSE 1 - 70 TLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEML 71 - 140 DSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTC 141 - 210 RTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGP 211 - 280 PLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHGADED 281 - 350 EDLFDIEDDIIYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMNGTEAAQLSTKSRAEGRAPNPARKACSA 351 - 420 SSKIRRLSACKQQ 421 - 433 //
