Tchem NCOA1 Nuclear receptor coactivator 1

Protein Summary

Description

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15788
• O00150
• O43792
• O43793
• Q13071
• Q13420
• Q2T9G5
• Q53SX3
• Q6GVI5
• Q7KYV3
• NCoA-1

Gene Name

• NCOA1

Ensembl ID

• ENST00000288599
• ENSP00000288599
• ENSG00000084676
• ENST00000348332
• ENSP00000320940
• ENST00000395856
• ENSP00000379197
• ENST00000405141
• ENSP00000385097
• ENST00000406961
• ENSP00000385216

Symbol

• BHLHE74
• SRC1
• SRC1
• KAT13A
• RIP160
• F-SRC-1
• bHLHe42
• bHLHe74

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
molecular function	1
protein domain	1
disease perturbation	0.99
kinase perturbation	0.99

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / Nuclear Receptor Coactivator 1

Protein / Transcription Factor / Nuclear Receptor Coactivator 1

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Src Family / Nuclear Receptor Coactivator 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 310.74   (req: < 5)

Gene RIFs: 87   (req: <= 3)

Antibodies: 388   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 310.74   (req: >= 5)

Gene RIFs: 87   (req: > 3)

Antibodies: 388   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0