1. Home
  2. Targets
  3. GPCR
  4. Class A rhodopsin like
  5. Neuropeptide Y receptor
  6. Neuropeptide Y receptor type 5

Tchem Neuropeptide Y receptor type 5

Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]

 Comments

Property Summary

NCBI Gene PubMed Count 35
PubMed Score 37.86
PubTator Score 89.11

Knowledge Summary

Patent (5,876)

TINX Plot

  Disease Sources (3)

Disease Target Count
Obesity 616
Disease Target Count P-value
psoriasis 6685 6.32133454044345E-38
invasive ductal carcinoma 2950 0.00528399406919983
astrocytic glioma 2241 0.0106077328140859
ductal carcinoma in situ 1745 0.0231449679633163
oligodendroglioma 2849 0.043102741866908
Disease Target Count Z-score Confidence
Spindle cell hemangioma 16 3.068 1.5

Expression

  Differential Expression (5)

Disease log2 FC p
astrocytic glioma -1.300 0.011
oligodendroglioma -1.300 0.043
ductal carcinoma in situ -1.500 0.023
invasive ductal carcinoma -1.900 0.005
psoriasis -1.600 0.000

Synonym

Accession Q15761 Q6GTR7 Q92916 NPY5-R
Symbols NPYR5
NPY5-R
NPYY5-R

Gene

NPY5R

PANTHER Protein Class (2)

PDB

2HE6  

  Ortholog (9)

Species Source
Chimp OMA EggNOG Inparanoid
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Platypus OMA EggNOG
Xenopus OMA EggNOG Inparanoid

  TechDev Info (1)

Bryan Roth functional assay

 Collection (1)

 GO Function (3)

 GO Component (4)

 GO Process (16)

See all...

 Compartment GO Term (12)

 MGI Term (5)

 HCA RNA Cell Line (11)

See all...

Pathway (10)

 UniProt Keyword (14)

See all...

Ligand (702)  

Structure of CHEMBL81337

CHEMBL81337
pIC50 7.00

Structure of CHEMBL82374

CHEMBL82374
pIC50 7.00

Structure of CHEMBL300543

CHEMBL300543
pKi 7.00

Structure of CHEMBL75662

CHEMBL75662
pIC50 7.00

Structure of CHEMBL139483

CHEMBL139483
pIC50 7.00

Structure of CHEMBL137404

CHEMBL137404
pIC50 7.00

Structure of CHEMBL1829318

CHEMBL1829318
pKi 7.01

Structure of CHEMBL52382

CHEMBL52382
pKi 7.02

Structure of CHEMBL468846

CHEMBL468846
pKi 7.03

Structure of CHEMBL294822

CHEMBL294822
pKi 7.03

Structure of CHEMBL506812

CHEMBL506812
pIC50 7.03

Structure of CHEMBL160722

CHEMBL160722
pKi 7.04

Structure of CHEMBL305987

CHEMBL305987
pIC50 7.04

Structure of CHEMBL350684

CHEMBL350684
pIC50 7.04

Structure of CHEMBL491020

CHEMBL491020
pIC50 7.04

Structure of CHEMBL495930

CHEMBL495930
pIC50 7.04

Structure of CHEMBL403282

CHEMBL403282
pKi 7.06

Structure of CHEMBL1829329

CHEMBL1829329
pKi 7.06

Structure of CHEMBL351082

CHEMBL351082
pIC50 7.07

Structure of CHEMBL484267

CHEMBL484267
pIC50 7.07

Gene RIF (26)

PMID Text
25132261 NPY5R is an inducible pro-survival factor that is responsible for chemoresistance in neuroblastoma cells.
23932937 these data highlight a novel mechanism by which NPY may promote breast cancer progression, and further implicate a pathological role of the NPY Y5R.
23900445 Variations in genes AGRP, CPE, GHRL, GLP1R, HTR2A, NPY1R, NPY5R, SOCS3 and STAT3 showed modest associations with BMI in European Americans.
20797317 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20602615 Observational study of gene-disease association. (HuGE Navigator)
20468064 Observational study of gene-disease association. (HuGE Navigator)
20332211 Together, our results suggest that Y5R plays an important role in cancer cell growth and migration and could be a novel therapeutic target for breast cancer.
19874574 Observational study of gene-disease association. (HuGE Navigator)
19759915 NPY1R and NPY5R have roles in nutrient-specific food intake in Europeans
19759915 Observational study of gene-disease association. (HuGE Navigator)
More...

AA Sequence 

MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKR      1 - 70
NQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRY     71 - 140
HMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIA    141 - 210
FTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYS    211 - 280
FIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHEL    281 - 350
RVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCL    351 - 420
NPILYGFLNNGIKADLVSLIHCLHM                                                 421 - 445
//

Text Mined References (37)

PMID Year Title
25132261 2015 Neuropeptide Y receptor Y5 as an inducible pro-survival factor in neuroblastoma: implications for tumor chemoresistance.
24681953 2015 Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation.
23932937 2013 Neuropeptide Y Y5-receptor activation on breast cancer cells acts as a paracrine system that stimulates VEGF expression and secretion to promote angiogenesis.
23900445 2014 Genetic association analysis of 30 genes related to obesity in a European American population.
22029806 2011 Expression of Neuropeptide Y, Substance P, and their receptors in the right atrium of diabetic patients.
20797317 2010 Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT.
20602615 2010 Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
20468064 2010 Association study of 182 candidate genes in anorexia nervosa.
20332211 2010 Neuropeptide Y Y5 receptor promotes cell growth through extracellular signal-regulated kinase signaling and cyclic AMP inhibition in a human breast cancer cell line.
19874574 2009 Genetical genomic determinants of alcohol consumption in rats and humans.
More...