| Tchem | Neuropeptide Y receptor type 5 |
The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
Comments
| Disease | Target Count |
|---|---|
| Alcohol abuse | 50 |
| Alcoholic Intoxication, Chronic | 289 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 6.3e-38 |
| invasive ductal carcinoma | 2951 | 5.3e-03 |
| astrocytic glioma | 2597 | 1.1e-02 |
| ductal carcinoma in situ | 1745 | 2.3e-02 |
| oligodendroglioma | 2850 | 4.3e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Spindle cell hemangioma | 16 | 3.106 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -1.300 | 1.1e-02 |
| ductal carcinoma in situ | -1.500 | 2.3e-02 |
| invasive ductal carcinoma | -1.900 | 5.3e-03 |
| oligodendroglioma | -1.300 | 4.3e-02 |
| psoriasis | -1.600 | 6.3e-38 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
CHEMBL81337
pIC50 7.00
CHEMBL82374
pIC50 7.00
CHEMBL300543
pKi 7.00
CHEMBL75662
pIC50 7.00
CHEMBL139483
pIC50 7.00
CHEMBL137404
pIC50 7.00
CHEMBL1829318
pKi 7.01
CHEMBL52382
pKi 7.02
CHEMBL468846
pKi 7.03
CHEMBL294822
pKi 7.03
CHEMBL506812
pIC50 7.03
CHEMBL160722
pKi 7.04
CHEMBL305987
pIC50 7.04
CHEMBL350684
pIC50 7.04
CHEMBL491020
pIC50 7.04
CHEMBL495930
pIC50 7.04
CHEMBL403282
pKi 7.06
CHEMBL1829329
pKi 7.06
CHEMBL351082
pIC50 7.07
CHEMBL484267
pIC50 7.07
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKR 1 - 70 NQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRY 71 - 140 HMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIA 141 - 210 FTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYS 211 - 280 FIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHEL 281 - 350 RVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCL 351 - 420 NPILYGFLNNGIKADLVSLIHCLHM 421 - 445 //
