Tchem | Neuropeptide Y receptor type 5 |
The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
Comments
Disease | Target Count | P-value |
---|---|---|
psoriasis | 6685 | 6.32133454044345E-38 |
invasive ductal carcinoma | 2950 | 0.00528399406919983 |
astrocytic glioma | 2241 | 0.0106077328140859 |
ductal carcinoma in situ | 1745 | 0.0231449679633163 |
oligodendroglioma | 2849 | 0.043102741866908 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Spindle cell hemangioma | 16 | 3.068 | 1.5 |
Disease | log2 FC | p |
---|---|---|
astrocytic glioma | -1.300 | 0.011 |
oligodendroglioma | -1.300 | 0.043 |
ductal carcinoma in situ | -1.500 | 0.023 |
invasive ductal carcinoma | -1.900 | 0.005 |
psoriasis | -1.600 | 0.000 |
Species | Source |
---|---|
Chimp | OMA EggNOG Inparanoid |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG |
Cow | OMA EggNOG Inparanoid |
Pig | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG |
Xenopus | OMA EggNOG Inparanoid |
CHEMBL81337
pIC50 7.00
CHEMBL82374
pIC50 7.00
CHEMBL300543
pKi 7.00
CHEMBL75662
pIC50 7.00
CHEMBL139483
pIC50 7.00
CHEMBL137404
pIC50 7.00
CHEMBL1829318
pKi 7.01
CHEMBL52382
pKi 7.02
CHEMBL468846
pKi 7.03
CHEMBL294822
pKi 7.03
CHEMBL506812
pIC50 7.03
CHEMBL160722
pKi 7.04
CHEMBL305987
pIC50 7.04
CHEMBL350684
pIC50 7.04
CHEMBL491020
pIC50 7.04
CHEMBL495930
pIC50 7.04
CHEMBL403282
pKi 7.06
CHEMBL1829329
pKi 7.06
CHEMBL351082
pIC50 7.07
CHEMBL484267
pIC50 7.07
PMID | Text |
---|---|
25132261 | NPY5R is an inducible pro-survival factor that is responsible for chemoresistance in neuroblastoma cells. |
23932937 | these data highlight a novel mechanism by which NPY may promote breast cancer progression, and further implicate a pathological role of the NPY Y5R. |
23900445 | Variations in genes AGRP, CPE, GHRL, GLP1R, HTR2A, NPY1R, NPY5R, SOCS3 and STAT3 showed modest associations with BMI in European Americans. |
20797317 | Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) |
20602615 | Observational study of gene-disease association. (HuGE Navigator) |
20468064 | Observational study of gene-disease association. (HuGE Navigator) |
20332211 | Together, our results suggest that Y5R plays an important role in cancer cell growth and migration and could be a novel therapeutic target for breast cancer. |
19874574 | Observational study of gene-disease association. (HuGE Navigator) |
19759915 | NPY1R and NPY5R have roles in nutrient-specific food intake in Europeans |
19759915 | Observational study of gene-disease association. (HuGE Navigator) |
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MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKR 1 - 70 NQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRY 71 - 140 HMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIA 141 - 210 FTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYS 211 - 280 FIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHEL 281 - 350 RVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCL 351 - 420 NPILYGFLNNGIKADLVSLIHCLHM 421 - 445 //
PMID | Year | Title |
---|---|---|
25132261 | 2015 | Neuropeptide Y receptor Y5 as an inducible pro-survival factor in neuroblastoma: implications for tumor chemoresistance. |
24681953 | 2015 | Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation. |
23932937 | 2013 | Neuropeptide Y Y5-receptor activation on breast cancer cells acts as a paracrine system that stimulates VEGF expression and secretion to promote angiogenesis. |
23900445 | 2014 | Genetic association analysis of 30 genes related to obesity in a European American population. |
22029806 | 2011 | Expression of Neuropeptide Y, Substance P, and their receptors in the right atrium of diabetic patients. |
20797317 | 2010 | Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT. |
20602615 | 2010 | Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? |
20468064 | 2010 | Association study of 182 candidate genes in anorexia nervosa. |
20332211 | 2010 | Neuropeptide Y Y5 receptor promotes cell growth through extracellular signal-regulated kinase signaling and cyclic AMP inhibition in a human breast cancer cell line. |
19874574 | 2009 | Genetical genomic determinants of alcohol consumption in rats and humans. |
More... |