You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
INPP5J
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

Protein Summary
Description
Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331075
  • ENSP00000333262
  • ENSG00000185133
  • ENST00000400294
  • ENSP00000383150
  • ENST00000404390
  • ENSP00000384534
  • ENST00000405300
  • ENSP00000384596

Symbol
  • PIB5PA
  • PIPP
  • PIPP
  • INPP5
  • PIB5PA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.76
gene perturbation
0.7
molecular function
0.7
pathway
0.7
disease perturbation
0.68


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.38   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.38   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0