| Tbio | Metastasis-suppressor KiSS-1 |
Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Mar 2012]
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Mar 2012]
Comments
| Disease | Target Count |
|---|---|
| Delayed Puberty | 10 |
| Lymphatic Metastasis | 14 |
| Squamous cell carcinoma of the head and neck | 24 |
| Stomach Neoplasms | 282 |
| Disease | Target Count | P-value |
|---|---|---|
| malignant mesothelioma | 3163 | 1.72167424609708E-6 |
| cystic fibrosis | 1670 | 5.85595102402534E-4 |
| psoriasis | 6685 | 0.0192375156071563 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Klinefelter's syndrome | 59 | 6.303 | 3.2 |
| Disease | Target Count |
|---|---|
| Hypogonadotropic hypogonadism | 20 |
| Hypogonadotropic hypogonadism 13 with or without anosmia | 1 |
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | 1.900 | 0.000 |
| cystic fibrosis | -1.432 | 0.001 |
| psoriasis | -1.100 | 0.019 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Opossum | OMA EggNOG Inparanoid |
| Platypus | OMA EggNOG |
| Xenopus | EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 26831552 | Data suggest that plasma kisspeptin and serum prolactin levels may be involved in the physiopathology of breast enlargement in newborns. |
| 26809635 | KiSS-1 downregulation may play a role in tumor progression and metastasis of oral squamous cell carcinoma, and may be a reliable biomarker for predicting clinical outcome in this disease. |
| 26572251 | KiSS1 is a metastasis suppressor gene of pancreatic cancer, and this suppression is not dependent on the expression levels of GPR54. |
| 26510589 | A number of mutations in KISS1 KISS1R are associated with central precocious puberty and isolated hypogonadotropic hypogonadism. (Review) |
| 26471489 | KISS1 Low Expression Correlates with Colorectal Liver Metastasis. |
| 26384646 | On D4 of pregnancy, the Kiss 1 null uterus expresses functional KISS1R molecules. |
| 26183891 | These findings are of tremendous significance and will greatly shape how KISS1 will be developed as a therapeutic agent in augmenting the reproductive potential of both women and important livestock species--{REVIEW} |
| 26010933 | KISS1 expression in the primary site of colorectal cancer could become a useful marker, with its increased levels indicating an advanced disease and a worse prognosis. |
| 25810563 | rs5780218 polymorphism individually confers susceptibility for development of breast cancer in Mexican population. |
| 25783047 | The results suggest that mutations in the coding sequence of KISS1 are not common in patients with IHH in this Chinese population. |
| More... |
| PMID | Year | Title |
|---|---|---|
| 26831552 | 2015 | Plasma Kisspeptin Levels in Newborn Infants with Breast Enlargement. |
| 26809635 | 2016 | KiSS-1 expression in oral squamous cell carcinoma and its prognostic significance. |
| 26572251 | 2016 | KiSS?1?mediated suppression of the invasive ability of human pancreatic carcinoma cells is not dependent on the level of KiSS?1 receptor GPR54. |
| 26510589 | [Kisspeptin and leptin in the regulation of fertility]. | |
| 26471489 | 2015 | KISS1 Associates with Better Outcome via Inhibiting Matrix Metalloproteinase-9 in Colorectal Liver Metastasis. |
| 26384646 | 2015 | The pregnant mouse uterus exhibits a functional kisspeptin/KISS1R signaling system on the day of embryo implantation. |
| 26183891 | 2015 | Uterine and placental KISS1 regulate pregnancy: what we know and the challenges that lie ahead. |
| 26010933 | 2015 | A clinicopathological analysis of KISS1 and KISS1R expression in colorectal cancer. |
| 25810563 | 2015 | Polymorphisms rs12998 and rs5780218 in KiSS1 suppressor metastasis gene in Mexican patients with breast cancer. |
| 25783047 | 2015 | Mutations in KISS1 are not responsible for idiopathic hypogonadotropic hypogonadism in Chinese patients. |
| More... |
