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Tbio
TSC22D1
TSC22 domain family protein 1

Protein Summary
Description
Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter. This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261489
  • ENSP00000261489
  • ENSG00000102804
  • ENST00000458659
  • ENSP00000397435
  • ENST00000501704
  • ENSP00000437414

Symbol
  • KIAA1994
  • TGFB1I4
  • TSC22
  • Ptg-2
  • TSC22
  • TGFB1I4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.98
kinase perturbation
0.91
PubMedID
0.91
transcription factor
0.89


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.24   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 395   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.24   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 395   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0